Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.
We don't have any images related to Pyrimidine analogue yet.
You can add one yourself here.
We don't have any YouTube videos related to Pyrimidine analogue yet.
You can add one yourself here.
We don't have any PDF documents related to Pyrimidine analogue yet.
You can add one yourself here.
We don't have any Books related to Pyrimidine analogue yet.
You can add one yourself here.
We don't have any archived web articles related to Pyrimidine analogue yet.
Examples
- Nucleobase analogues
- Fluorouracil (5FU), which inhibits thymidylate synthase
- Floxuridine (FUDR)
- 6-azauracil (6-AU)
- Nucleoside analogues
- Cytarabine (Cytosine arabinoside)
- Gemcitabine
- Nucleotide analogues
Medical uses
Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication.1
References
Parker, William B. (2009). "Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer". Chem Rev. 109 (7): 2880–2893. doi:10.1021/cr900028p. PMC 2827868. PMID 19476376. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827868 ↩