Pyrimidine analogue

<h2 id="examples">Examples</h2>
<ul><li><a href="/facts/Nucleobase_analogue/eawesy51">Nucleobase analogues</a>
<ul><li><a href="/facts/Fluorouracil/6xH4uUaf">Fluorouracil</a> (5FU), which inhibits <a href="/facts/Thymidylate_synthase/zKtHApFJ">thymidylate synthase</a></li>
<li><a href="/facts/Floxuridine/NcV7amVC">Floxuridine</a> (FUDR)</li>
<li>6-azauracil (6-AU)</li></ul></li>
<li><a href="/facts/Nucleoside_analogue/DEr9cQYD">Nucleoside analogues</a>
<ul><li><a href="/facts/Cytarabine/9vfbHUMf">Cytarabine</a> (Cytosine arabinoside)</li>
<li><a href="/facts/Gemcitabine/PTFS54zl">Gemcitabine</a></li></ul></li>
<li>Nucleotide analogues</li></ul>

<h2 id="medical-uses">Medical uses</h2>
<p>Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication.<a class="footnote-ref" id="fnref:1" href="#fn:1"><sup>1</sup></a>
</p>

<h2 id="references">References</h2>

<ol>
<li id="fn:1"><p>Parker, William B. (2009). "Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer". Chem Rev. 109 (7): 2880–2893. doi:10.1021/cr900028p. PMC 2827868. PMID 19476376. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827868" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827868</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li>
</ol>

Pyrimidine analogue open-in-new

Pyrimidine analogue