Pinc (pregnancy induced noncoding RNA) is a long non-coding RNA. It was originally identified in the mammary glands of oestrogen and progesterone-treated rats. Pinc may be a mammal-specific gene. It is conserved in a number of mammalian genomes (human, mouse, rat, chimpanzee, dog, cow and opossum), but not in fugu, zebrafish or xenopus genomes.
In mice, Pinc is expressed in the developing embryo and in the mammary glands of adults. Its expression in the mammary gland is induced by pregnancy and drops during lactation. It may have a role in cell survival and in the regulation of cell cycle progression.
See also
Further reading
- Mattick JS (April 2009). Lee, Jeannie T. (ed.). "The genetic signatures of noncoding RNAs". PLOS Genet. 5 (4): e1000459. doi:10.1371/journal.pgen.1000459. PMC 2667263. PMID 19390609.
External links
References
Ginger MR, Gonzalez-Rimbau MF, Gay JP, Rosen JM (November 2001). "Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland". Mol. Endocrinol. 15 (11): 1993–2009. doi:10.1210/mend.15.11.0724. PMID 11682629. /wiki/Jeffrey_M._Rosen ↩
Ginger MR, Shore AN, Contreras A, et al. (April 2006). "A noncoding RNA is a potential marker of cell fate during mammary gland development". Proc. Natl. Acad. Sci. U.S.A. 103 (15): 5781–5786. Bibcode:2006PNAS..103.5781G. doi:10.1073/pnas.0600745103. PMC 1420634. PMID 16574773. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420634 ↩
Ginger MR, Shore AN, Contreras A, et al. (April 2006). "A noncoding RNA is a potential marker of cell fate during mammary gland development". Proc. Natl. Acad. Sci. U.S.A. 103 (15): 5781–5786. Bibcode:2006PNAS..103.5781G. doi:10.1073/pnas.0600745103. PMC 1420634. PMID 16574773. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420634 ↩