In vivo supersaturation - Reference.org

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In vivo supersaturation

A phenomenon in which a weakly basic drug becomes supersaturated as it travels through the gastrointestinal tract

In vivo supersaturation is the behavior of orally administered compounds that undergo supersaturation as they pass through the gastrointestinal (GI) tract. Typically these compounds have a weakly basic nature (pKa in the range of 5 to 8) and a relatively low solubility in aqueous solutions. In vivo supersaturation is a recent phenomenon that was first observed by Yamashita et al. in 2003.

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References

Hsieh, Yi-Ling; Ilevbare, Grace A.; Van Eerdenbrugh, Bernard; Box, Karl J.; Sanchez-Felix, Manuel Vincente; Taylor, Lynne S. (2012-05-12). "pH-Induced Precipitation Behavior of Weakly Basic Compounds: Determination of Extent and Duration of Supersaturation Using Potentiometric Titration and Correlation to Solid State Properties". Pharmaceutical Research. 29 (10): 2738–2753. doi:10.1007/s11095-012-0759-8. ISSN 0724-8741. PMID 22580905. S2CID 15502736. /wiki/Doi_(identifier) ↩
Yamashita, Kazunari; Nakate, Toshiomi; Okimoto, Kazuto; Ohike, Atsuo; Tokunaga, Yuji; Ibuki, Rinta; Higaki, Kazutaka; Kimura, Toshikiro (November 2003). "Establishment of new preparation method for solid dispersion formulation of tacrolimus". International Journal of Pharmaceutics. 267 (1–2): 79–91. doi:10.1016/j.ijpharm.2003.07.010. ISSN 0378-5173. PMID 14602386. /wiki/Doi_(identifier) ↩