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Reference.org
In vivo supersaturation
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<p>In vivo supersaturation is the behavior of orally administered compounds that undergo <a href="/facts/Supersaturation/YaTN0D1L">supersaturation</a> as they pass through the <a href="/facts/Gastrointestinal_tract/nK2zwqBS">gastrointestinal (GI) tract</a>. Typically these compounds have a weakly basic nature (<a href="/facts/Acid_dissociation_constant/t4YyRtKC">p<i>K</i>a</a> in the range of 5 to 8) and a relatively low solubility in aqueous solutions. In vivo supersaturation is a recent phenomenon that was first observed by Yamashita et al. in 2003. </p>