Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly). Hepatosplenomegaly can occur as the result of acute viral hepatitis, infectious mononucleosis, and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage disease. Systemic venous hypertension can also increase the risk for developing hepatosplenomegaly, which may be seen in those patients with right-sided heart failure.
Common causes
- Infection:
- Acute viral hepatitis12
- Infectious mononucleosis34
- Cytomegalovirus56
- Rubella7
- Brucella infection8
- Hyper active malaria syndrome9
- Leishmaniasis10
- Fasciolosis
- Typhoid fever11
- Schistosomiasis or filariasis importants
- Septicemic plague
- Histoplasmosis
- Hematologic diseases:
- Metabolic disease:
- Chronic liver disease and portal hypertension:
- Amyloidosis25
- Acromegaly26
- Systemic lupus erythematosus27
- Sarcoidosis
- Human African trypanosomiasis
- Drug abuse
- Obesity
Rare disorders
Are the following:
- Lipoproteinlipase deficiency
- Multiple sulfatase deficiency
- Osteopetrosis
- Adult-onset Still's disease (AOSD)
External links
References
medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.medcyclopaedia.com/library/topics/volume_vii/h/HEPATOSPLENOMEGALY.aspx ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.medcyclopaedia.com/library/topics/volume_vii/h/HEPATOSPLENOMEGALY.aspx ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.medcyclopaedia.com/library/topics/volume_vii/h/HEPATOSPLENOMEGALY.aspx ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.medcyclopaedia.com/library/topics/volume_vii/h/HEPATOSPLENOMEGALY.aspx ↩
Xavier, Mariana (2010). "Pathogenesis of Brucella spp". The Open Veterinary Science Journal. 4: 109–118. doi:10.2174/1874318801004010109. https://doi.org/10.2174%2F1874318801004010109 ↩
medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.medcyclopaedia.com/library/topics/volume_vii/h/HEPATOSPLENOMEGALY.aspx ↩
medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.medcyclopaedia.com/library/topics/volume_vii/h/HEPATOSPLENOMEGALY.aspx ↩
"Typhoid & Paratyphoid Fever - Chapter 3 - 2016 Yellow Book - Travelers' Health - CDC". https://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/typhoid-paratyphoid-fever#4723 ↩
medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.medcyclopaedia.com/library/topics/volume_vii/h/HEPATOSPLENOMEGALY.aspx ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.medcyclopaedia.com/library/topics/volume_vii/h/HEPATOSPLENOMEGALY.aspx ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.medcyclopaedia.com/library/topics/volume_vii/h/HEPATOSPLENOMEGALY.aspx ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.medcyclopaedia.com/library/topics/volume_vii/h/HEPATOSPLENOMEGALY.aspx ↩
"Niemann-Pick disease". Genetics Home Reference. Retrieved 18 Sep 2020. https://ghr.nlm.nih.gov/condition/niemann-pick-disease ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩
GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009 http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 ↩