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Reference.org
Hepatosplenomegaly
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<p>Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the <a href="/facts/Liver/Rtp4Fk2b">liver</a> (<a href="/facts/Hepatomegaly/zbVkL3aX">hepatomegaly</a>) and the <a href="/facts/Spleen/6NKn9d8s">spleen</a> (<a href="/facts/Splenomegaly/hkB1jTdo">splenomegaly</a>). Hepatosplenomegaly can occur as the result of acute <a href="/facts/Viral_hepatitis/DjT90Yhf">viral hepatitis</a>, <a href="/facts/Infectious_mononucleosis/pTwDw4VF">infectious mononucleosis</a>, and <a href="/facts/Histoplasmosis/FfMdb5m8">histoplasmosis</a> or it can be the sign of a serious and life-threatening <a href="/facts/Lysosomal_storage_disease/52yz22rF">lysosomal storage disease</a>. Systemic venous hypertension can also increase the risk for developing hepatosplenomegaly, which may be seen in those patients with right-sided <a href="/facts/Heart_failure/7fckX3Jm">heart failure</a>. </p>