Corynebacterium is a genus of Gram-positive bacteria and most are aerobic. They are bacilli (rod-shaped), and in some phases of life they are, more specifically, club-shaped, which inspired the genus name (coryneform means "club-shaped").
They are widely distributed in nature in the microbiota of animals (including the human microbiota) and are mostly innocuous, most commonly existing in commensal relationships with their hosts. Some, such as C. glutamicum, are commercially and industrially useful. Others can cause human disease, including, most notably, diphtheria, which is caused by C. diphtheriae. Like various species of microbiota (including their relatives in the genera Arcanobacterium and Trueperella), they are usually not pathogenic, but can occasionally capitalize opportunistically on atypical access to tissues (via wounds) or weakened host defenses.