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Corynebacterium glutamicum
Species of bacterium

Corynebacterium glutamicum is a Gram-positive, rod-shaped bacterium that is used industrially for large-scale production of amino acids, especially glutamic acid and lysine. While originally identified in a screen for organisms secreting L-glutamate, mutants of C. glutamicum have also been identified that produce various other amino acids and derivatives of amino acids.

Due to its industrial importance, several clones of C. glutamicum have been sequenced by both industry and academic groups. Furthermore, small RNA data was obtained by RNA-Seq in C. glutamicum ATCC 13032. The metabolism of this strain has been reconstructed and is available in the form of a genome-scale metabolic model.

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See also

References

  1. Kinoshita, Shukuo; Udaka, Shigezo; Shimono, Masakazu (1957), "Studies on the amino acid fermentation. Part 1. Production of L-glutamic acid by various microorganisms", Journal of General and Applied Microbiology, 3 (3): 193–205, doi:10.2323/jgam.3.193, PMID 15965888{{citation}}: CS1 maint: multiple names: authors list (link) /wiki/Doi_(identifier) ↩

  2. Udaka, Shigezo (1960), "Screening method for microorganisms accumulating metabolites and its use in the isolation of Micrococcus glutamicus", Journal of Bacteriology, 79 (5): 754–755, doi:10.1128/jb.79.5.754-755.1960, PMC 278770, PMID 13840150 /wiki/Doi_(identifier) ↩

  3. Kalinowski, J; Bathe, B; Bartels, D; et al. (4 September 2003). "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of l-aspartate-derived amino acids and vitamins". Journal of Biotechnology. 104 (1–3): 5–25. doi:10.1016/S0168-1656(03)00154-8. PMID 12948626. /wiki/Doi_(identifier) ↩

  4. Zahoor A; Lindner SN; Wendisch VF (October 2012). "Metabolic Engineering of Corynebacterium glutamicum Aimed at Alternative Carbon Sources and New Products". Computational and Structural Biotechnology Journal. 3 (4): e201210004. doi:10.5936/csbj.201210004. PMC 3962153. PMID 24688664. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962153 ↩

  5. Kalinowski, J; Bathe, B; Bartels, D; et al. (4 September 2003). "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of l-aspartate-derived amino acids and vitamins". Journal of Biotechnology. 104 (1–3): 5–25. doi:10.1016/S0168-1656(03)00154-8. PMID 12948626. /wiki/Doi_(identifier) ↩

  6. Mentz, Almut; Neshat, Armin; Pfeifer-Sancar, Katharina; et al. (2013-10-19). "Comprehensive discovery and characterization of small RNAs in Corynebacterium glutamicum ATCC 13032". BMC Genomics. 14 (1): 714. doi:10.1186/1471-2164-14-714. ISSN 1471-2164. PMC 4046766. PMID 24138339. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046766 ↩

  7. Feierabend, Martina; Renz, Alina; Zelle, Elisabeth; et al. (2021). "High-Quality Genome-Scale Reconstruction of Corynebacterium glutamicum ATCC 13032". Frontiers in Microbiology. 12 (10): 3432. doi:10.3389/fmicb.2021.750206. ISSN 1664-302X. PMC 8634658. PMID 34867870. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634658 ↩