Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.
HES5 regulates the development of the early brain by maintaining stem cell neural progenitors in the ventricular zone. HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia. Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.
Further reading
- Gazit R, Krizhanovsky V, Ben-Arie N (February 2004). "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway". Development. 131 (4): 903–913. doi:10.1242/dev.00982. PMID 14757642. S2CID 44769279.
- Nakatani T, Mizuhara E, Minaki Y, Sakamoto Y, Ono Y (April 2004). "Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system". The Journal of Biological Chemistry. 279 (16): 16356–16367. doi:10.1074/jbc.M311740200. PMID 14764602.
- Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y (June 2004). "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling". Nature Cell Biology. 6 (6): 547–554. doi:10.1038/ncb1138. PMID 15156153. S2CID 36887899.
- Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–534. doi:10.3892/ijo.25.2.529. PMID 15254753.
- Ohtsuka T, Imayoshi I, Shimojo H, Nishi E, Kageyama R, McConnell SK (January 2006). "Visualization of embryonic neural stem cells using Hes promoters in transgenic mice". Molecular and Cellular Neurosciences. 31 (1): 109–122. doi:10.1016/j.mcn.2005.09.006. PMID 16214363. S2CID 35470002.
- Ong CT, Cheng HT, Chang LW, Ohtsuka T, Kageyama R, Stormo GD, Kopan R (February 2006). "Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability". The Journal of Biological Chemistry. 281 (8): 5106–5119. doi:10.1074/jbc.M506108200. PMID 16365048.
- Karlsson C, Brantsing C, Svensson T, Brisby H, Asp J, Tallheden T, Lindahl A (February 2007). "Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors". Journal of Orthopaedic Research. 25 (2): 152–163. doi:10.1002/jor.20287. PMID 17072841.
- Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell and Tissue Research. 327 (3): 539–551. doi:10.1007/s00441-006-0307-0. PMID 17093926. S2CID 33749726.
External links
- HES5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
References
Takebayashi K, Akazawa C, Nakanishi S, Kageyama R (January 1995). "Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element". The Journal of Biological Chemistry. 270 (3): 1342–1349. doi:10.1074/jbc.270.3.1342. PMID 7836401. https://doi.org/10.1074%2Fjbc.270.3.1342 ↩
"Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=388585 ↩
Ohtsuka T, Sakamoto M, Guillemot F, Kageyama R (August 2001). "Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain". The Journal of Biological Chemistry. 276 (32): 30467–30474. doi:10.1074/jbc.M102420200. PMID 11399758. https://doi.org/10.1074%2Fjbc.M102420200 ↩
Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R (November 2004). "Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation". Development. 131 (22): 5539–5550. doi:10.1242/dev.01436. hdl:2433/144732. PMID 15496443. https://doi.org/10.1242%2Fdev.01436 ↩
Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X (2007). "Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors". International Journal of Gynecological Cancer. 17 (6): 1293–1299. doi:10.1111/j.1525-1438.2007.00930.x. PMID 17388915. S2CID 25609083. https://doi.org/10.1111%2Fj.1525-1438.2007.00930.x ↩
Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell and Tissue Research. 327 (3): 539–551. doi:10.1007/s00441-006-0307-0. PMID 17093926. S2CID 33749726. /wiki/Doi_(identifier) ↩