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Cluster headache
Neurological disorder

Cluster headache is a neurological disorder causing severe headaches typically around one eye, often with nasal congestion and eye watering. These attacks last 15 minutes to 3 hours and occur in clusters over weeks or months. Likely linked to posterior hypothalamus dysfunction, risk factors include tobacco smoke exposure and family history. Triggers may include alcohol and nitroglycerin. Management involves lifestyle changes and acute treatments like oxygen or triptans. Preventative options include steroid injections and galcanezumab. Affecting about 0.1% of people, cluster headaches more commonly begin between ages 20-40 and affect men more than women.

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Signs and symptoms

Cluster headaches are recurring bouts of severe unilateral headache attacks.2425 The duration of a typical cluster headache ranges from about 15 to 180 minutes.26 About 75% of untreated attacks last less than 60 minutes.27 However, women may have longer and more severe cluster headaches.28

The onset of an attack is rapid and typically without an aura. Preliminary sensations of pain in the general area of attack, referred to as "shadows", may signal an imminent cluster headache, or these symptoms may linger after an attack has passed, or between attacks.29 Though cluster headaches are strictly unilateral, there are some documented cases of "side-shift" between cluster periods,30 or, rarely, simultaneous (within the same cluster period) bilateral cluster headaches.31

Pain

The pain occurs only on one side of the head, around the eye, particularly behind or above the eye, in the temple. The pain is typically greater than in other headache conditions, including migraines, and is usually described as burning, stabbing, drilling or squeezing.32 While suicide is rare, those with cluster headaches may experience suicidal thoughts (giving the alternative name "suicide headache" or "suicidal headache").3334 The disease is considered among the most painful conditions known to medical science.3536

Dr. Peter Goadsby, Professor of Clinical Neurology at University College London, a leading researcher on the condition has commented:

"Cluster headache is probably the worst pain that humans experience. I know that's quite a strong remark to make, but if you ask a cluster headache patient if they've had a worse experience, they'll universally say they haven't. Women with cluster headache will tell you that an attack is worse than giving birth. So you can imagine that these people give birth without anesthetic once or twice a day, for six, eight, or ten weeks at a time, and then have a break. It's just awful."37

Other symptoms

The typical symptoms of cluster headache include grouped occurrence and recurrence (cluster) of headache attack, severe unilateral orbital, supraorbital and/or temporal pain. If left untreated, attack frequency may range from one attack every two days to eight attacks per day.3839 Cluster headache attack is accompanied by at least one of the following autonomic symptoms: drooping eyelid, pupil constriction, redness of the conjunctiva, tearing, runny nose and less commonly, facial blushing, swelling, or sweating, typically appearing on the same side of the head as the pain.40 Similar to a migraine, sensitivity to light (photophobia) or noise (hyperacusis) may occur during a cluster headache. Nausea is a rare symptom although it has been reported.41

Restlessness (for example, pacing or rocking back and forth) may occur. Secondary effects may include the inability to organize thoughts and plans, physical exhaustion, confusion, agitation, aggressiveness, depression, and anxiety.42

People with cluster headaches may dread facing another headache and adjust their physical or social activities around a possible future occurrence. Likewise they may seek assistance to accomplish what would otherwise be normal tasks. They may hesitate to make plans because of the regularity, or conversely, the unpredictability of the pain schedule. These factors can lead to generalized anxiety disorders, panic disorder,43 serious depressive disorders,44 social withdrawal and isolation.45

Cluster headaches have been recently associated with obstructive sleep apnea comorbidity.46

Recurrence

Cluster headaches may occasionally be referred to as "alarm clock headache" because of the regularity of their recurrence. Cluster headaches often awaken individuals from sleep. Both individual attacks and the cluster grouping can have a metronomic regularity; attacks typically strike at a precise time of day each morning or night. The recurrence of headache cluster grouping may occur more often around solstices, or seasonal changes, sometimes showing circannual periodicity. Conversely, attack frequency may be highly unpredictable, showing no periodicity at all. These observations have prompted researchers to speculate an involvement or dysfunction of the hypothalamus. The hypothalamus controls the body's "biological clock" and circadian rhythm.4748 In episodic cluster headache, attacks occur once or more daily, often at the same time each day for a period of several weeks, followed by a headache-free period lasting weeks, months, or years. Approximately 10–15% of cluster headaches are chronic, with multiple headaches occurring every day for years, sometimes without any remission.49

In accordance with the International Headache Society (IHS) diagnostic criteria, cluster headaches occurring in two or more cluster periods, lasting from 7 to 365 days with a pain-free remission of one month or longer between the headache attacks may be classified as episodic. If headache attacks occur for more than a year without pain-free remission of at least three months, the condition is classified as chronic.50 Chronic cluster headaches both occur and recur without any remission periods between cycles; there may be variation in cycles, meaning the frequency and severity of attacks may change without predictability for a period of time. The frequency, severity, and duration of headache attacks experienced by people during these cycles varies between individuals and does not demonstrate complete remission of the episodic form. The condition may change unpredictably from chronic to episodic and from episodic to chronic.51

Causes

Positron emission tomography (PET) shows brain areas being activated during pain.
Voxel-based morphometry shows brain area structural differences.

The specific causes and pathogenesis of cluster headaches are not fully understood.52 The Third Edition of the International Classification of Headache disorders classifies cluster headaches as belonging to the trigeminal autonomic cephalalgias.53

Some experts consider the posterior hypothalamus to be important in the pathogenesis of cluster headaches. This is supported by a relatively high success ratio of deep-brain stimulation therapy on the posterior hypothalamic grey matter.54

Nerves

Therapies acting on the vagus nerve (cranial nerve X) and the greater occipital nerve have both shown efficacy in managing cluster headache, but the specific roles of these nerves are not well-understood.55 Two nerves thought to play an important role in cluster headaches include the trigeminal nerve and the facial nerve.56

Genetics

Cluster headache may run in some families in an autosomal dominant inheritance pattern.5758 People with a first degree relative with the condition are about 14–48 times more likely to develop it themselves,59 and around 8 to 10% of persons with cluster headaches have a family history.6061 Several studies have found a higher number of relatives affected among females.62 Others have suggested these observations may be due to lower numbers of females in these studies.63 Possible genetic factors warrant further research, current evidence for genetic inheritance is limited.64

Genes that are thought to play a role in the disease are the hypocretin/orexin receptor type 2 (HCRTR2), alcohol dehydrogenase 4(ADH4), G protein beta 3 (GNB3), pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1), and membrane metalloendopeptidase (MME) genes.65

Tobacco smoking

About 65% of persons with cluster headache are, or have been, tobacco smokers.66 Stopping smoking does not lead to improvement of the condition, and cluster headaches also occur in those who have never smoked (e.g., children);67 it is thought unlikely that smoking is a cause.68 People with cluster headaches may be predisposed to certain traits, including smoking or other lifestyle habits.69

Hypothalamus

A review suggests that the suprachiasmatic nucleus of the hypothalamus, which is the major biological clock in the human body, may be involved in cluster headaches, because cluster headaches occur with diurnal and seasonal rhythmicity.70

Positron emission tomography (PET) scans indicate the brain areas which are activated during attack only, compared to pain free periods. These pictures show brain areas that are active during pain in yellow/orange color (called "pain matrix"). The area in the center (in all three views) is activated only during cluster headaches. The bottom row voxel-based morphometry shows structural brain differences between individuals with and without CH; only a portion of the hypothalamus is different.71

Diagnosis

Cluster-like head pain may be diagnosed as secondary headache rather than cluster headache.72

A detailed oral history aids practitioners in correct differential diagnosis, as there are no confirmatory tests for cluster headache. A headache diary can be useful in tracking when and where pain occurs, how severe it is, and how long the pain lasts. A record of coping strategies used may help distinguish between headache type; data on frequency, severity and duration of headache attacks are a necessary tool for initial and correct differential diagnosis in headache conditions.73

Correct diagnosis presents a challenge as the first cluster headache attack may present where staff are not trained in the diagnosis of rare or complex chronic disease.74 Experienced ER staff are sometimes trained to detect headache types.75 While cluster headache attacks themselves are not directly life-threatening, suicide ideation has been observed.76

Individuals with cluster headaches typically experience diagnostic delay before correct diagnosis.77 People are often misdiagnosed due to reported neck, tooth, jaw, and sinus symptoms and may unnecessarily endure many years of referral to ear, nose and throat (ENT) specialists for investigation of sinuses; dentists for tooth assessment; chiropractors and manipulative therapists for treatment; or psychiatrists, psychologists, and other medical disciplines before their headaches are correctly diagnosed.78 Under-recognition of cluster headaches by health care professionals is reflected in consistent findings in Europe and the United States that the average time to diagnosis is around seven years.79

Differential

Cluster headache may be misdiagnosed as migraine or sinusitis.80 Other types of headache are sometimes mistaken for, or may mimic closely, cluster headaches. Incorrect terms like "cluster migraine" confuse headache types, confound differential diagnosis and are often the cause of unnecessary diagnostic delay,81 ultimately delaying appropriate specialist treatment.

Other types of headaches that may be confused with cluster headache include:

Prevention

Management for cluster headache is divided into three primary categories: abortive, transitional, and preventive.90 Preventive treatments are used to reduce or eliminate cluster headache attacks; they are generally used in combination with abortive and transitional techniques.91

Verapamil

The recommended first-line preventive therapy is verapamil, a calcium channel blocker.9293 Verapamil was previously underused in people with cluster headache.94 Improvement can be seen in an average of 1.7 weeks for episodic cluster headache and 5 weeks for chronic cluster headache when using a dosage of ranged between 160 and 720 mg (mean 240 mg/day).95 Preventive therapy with verapamil is believed to work because it has an effect on the circadian rhythm and on CGRPs as CGRP-release is controlled by voltage-gated calcium channels.96

Glucocorticoids

Since these compounds are steroids, there is little evidence to support long-term benefits from glucocorticoids,97 but they may be used until other medications take effect as they appear to be effective at three days.98 They are generally discontinued after 8–10 days of treatment.99 Prednisone is given at a starting dose of 60–80 milligrams daily; then it is reduced by 5 milligrams every day. Corticosteroids are also used to break cycles, especially in chronic patients.100

Surgery

Nerve stimulators may be an option in the small number of people who do not improve with medications.101102 Two procedures, deep brain stimulation or occipital nerve stimulation, may be useful;103 early experience shows a benefit in about 60% of cases.104 It typically takes weeks or months for this benefit to appear.105 A non-invasive method using transcutaneous electrical nerve stimulation (TENS) is being studied.106

A number of surgical procedures, such as a rhizotomy or microvascular decompression, may also be considered,107 but evidence to support them is limited and there are cases of people whose symptoms worsen after these procedures.108

Other

Lithium, methysergide, and topiramate are recommended alternative treatments,109110 although there is little evidence supporting the use of topiramate or methysergide.111112 This is also true for tianeptine, melatonin, and ergotamine.113 Valproate, sumatriptan, and oxygen are not recommended as preventive measures.114 Botulinum toxin injections have shown limited success.115 Evidence for baclofen, botulinum toxin, and capsaicin is unclear.116

Management

There are two primary treatments for acute CH: oxygen and triptans,117 but they are underused due to misdiagnosis of the syndrome.118 During bouts of headaches, triggers such as alcohol, nitroglycerine, and naps during the day should be avoided.119

Oxygen

Oxygen therapy may help to abort attacks, though it does not prevent future episodes.120 Typically it is given via a non-rebreather mask at 12–15 liters per minute for 15–20 minutes.121 One review found about 70% of patients improve within 15 minutes.122 The evidence for effectiveness of 100% oxygen, however, is weak.123124 Hyperbaric oxygen at pressures of ~2 times greater than atmospheric pressure may relieve cluster headaches.125

Triptans

The other primarily recommended treatment of acute attacks is subcutaneous or intranasal sumatriptan.126127 Sumatriptan and zolmitriptan have both been shown to improve symptoms during an attack with sumatriptan being superior.128 Because of the vasoconstrictive side-effect of triptans, they may be contraindicated in people with ischemic heart disease.129 The vasoconstrictor ergot compounds may be useful,130 but have not been well studied in acute attacks.131

Opioids

The use of opioid medication in management of cluster headache is not recommended132 and may make headache syndromes worse.133134 Long-term opioid use is associated with well known dependency, addiction, and withdrawal syndromes.135 Prescription of opioid medication may additionally lead to further delay in differential diagnosis, undertreatment, and mismanagement.136

Other

Intranasal lidocaine (sprayed in the ipsilateral nostril) may be an effective treatment with patient resistant to more conventional treatment.137

Octreotide administered subcutaneously has been demonstrated to be more effective than placebo for the treatment of acute attacks.138

Sub-occipital steroid injections have shown benefit and are recommended for use as a transitional therapy to provide temporary headache relief as more long term prophylactic therapies are instituted.139

Epidemiology

Cluster headache affects about 0.1% of the general population at some point in their life.140 Males are affected about four times more often than females.141 The condition usually starts between the ages of 20 and 50 years, although it can occur at any age.142 About one in five affected adults report the onset of cluster headache between 10 and 19 years of age.143

History

The first complete description of cluster headache was given by the London neurologist Wilfred Harris in 1926, who named the disease migrainous neuralgia.144145146 Descriptions of cluster headache date to 1745 and probably earlier.147

The condition was originally named Horton's cephalalgia after Bayard Taylor Horton, a US neurologist who postulated the first theory as to their pathogenesis. His original paper describes the severity of the headaches as being able to take normal men and force them to attempt or die by suicide; his 1939 paper said:

"Our patients were disabled by the disorder and suffered from bouts of pain from two to twenty times a week. They had found no relief from the usual methods of treatment. Their pain was so severe that several of them had to be constantly watched for fear of suicide. Most of them were willing to submit to any operation which might bring relief."148

CH has alternately been called erythroprosopalgia of Bing, ciliary neuralgia, erythromelalgia of the head, Horton's headache, histaminic cephalalgia, petrosal neuralgia, sphenopalatine neuralgia, vidian neuralgia, Sluder's neuralgia, Sluder's syndrome, and hemicrania angioparalyticia.149

Society and culture

Robert Shapiro, a professor of neurology, says that while cluster headaches are about as common as multiple sclerosis with a similar disability level, as of 2013, the US National Institutes of Health had spent $1.872 billion on research into multiple sclerosis in one decade, but less than $2 million on cluster headache research in 25 years.150

Research directions

Some case reports suggest that ingesting tryptamines such as LSD, psilocybin (as found in hallucinogenic mushrooms), or DMT can abort attacks and interrupt cluster headache cycles.151152 The hallucinogen DMT has a chemical structure that is similar to the triptan sumatriptan, indicating a possible shared mechanism in preventing or stopping migraine and TACs.153 In a 2006 survey of 53 individuals, 18 of 19 psilocybin users reported extended remission periods. The survey was not a blinded or a controlled study, and was "limited by recall and selection bias".154 The safety and efficacy of psilocybin is currently being studied in cluster headache, with the extension phase of one randomized controlled trial demonstrating reduced cluster attack burden after a 3-dose pulse of psilocybin.155156157 In Canada, a first cluster headache patient gained access to psychedelic-assisted therapy via Canada’s special access scheme for psilocybin.158

Fremanezumab, a humanized monoclonal antibody directed against calcitonin gene-related peptides alpha and beta, was in phase 3 clinical trials for cluster headaches, but the studies were stopped early due to a futility analysis demonstrating that a successful outcome was unlikely.159160

References

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