Formimidoyltransferase cyclodeaminase or formiminotransferase cyclodeaminase (gene symbol FTCD in humans) is a bifunctional enzyme that catalyzes the following reactions:
- conversion of formiminoglutamate and tetrahydrofolate into formiminotetrahydrofolate and glutamate (glutamate formimidoyltransferase activity, EC 2.1.2.5)
- subsequent deamination of formiminotetrahydrofolate to 5,10-methenyltetrahydrofolate and ammonia (formimidoyltetrahydrofolate cyclodeaminase activity, EC 4.3.1.4)
Its name comes from the two activities it catalyzes.
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Role in pathology
Mutations of the FTCD gene cause glutamate formiminotransferase deficiency.2
See also
References
"Glutamate formiminotransferase deficiency". NIH. GARD. August 10, 2016. Retrieved December 21, 2020. https://rarediseases.info.nih.gov/diseases/9279/glutamate-formiminotransferase-deficiency ↩
"Glutamate formiminotransferase deficiency". NIH. GARD. August 10, 2016. Retrieved December 21, 2020. https://rarediseases.info.nih.gov/diseases/9279/glutamate-formiminotransferase-deficiency ↩