The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center.
It is also known as the "corona".
It contains transient lymphocytes.
It is the location of the lymphoma in mantle cell lymphoma.
Pathology
Mantle zone expansion may be seen in benign, such as Castleman disease, and malignancy, i.e., Mantle cell lymphoma. Tcl-1 is expressed in the mantle zone.
External links
- https://web.archive.org/web/20080813003821/http://erl.pathology.iupui.edu/HISTO/LABE109.HTM
- Histology image: 07102loa – Histology Learning System at Boston University — "Lymphoid Tissues and Organs: lymph node, cortex and medulla"
References
"University of Cambridge: Department of Pathology". Archived from the original on 2008-06-03. Retrieved 2008-07-29. https://web.archive.org/web/20080603110413/http://teaching.path.cam.ac.uk/partIB_pract/P05/ ↩
"Lymph Nodes". Archived from the original on 2008-03-17. Retrieved 2008-07-29. https://web.archive.org/web/20080317074847/http://www3.umdnj.edu/histsweb/lab12/lab12nodes.html ↩
"Pathology of lymph nodes – Dr. Levy". www.dartmouth.edu. Archived from the original on 1999-11-05. https://web.archive.org/web/19991105133631/http://www.dartmouth.edu/~nlevy/levylecture.html ↩