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Signs and symptoms

People with hypothyroidism often have no or only mild symptoms. Numerous symptoms and signs are associated with hypothyroidism and can be related to the underlying cause, or a direct effect of not having enough thyroid hormones.²⁴²⁵ Many symptoms of hypothyroidism are otherwise common and do not necessarily indicate thyroid problem.²⁶ Hashimoto's thyroiditis may present with the mass effect of a goiter (enlarged thyroid gland).²⁷ In middle-aged women, the symptoms may be mistaken for those of menopause.²⁸

Delayed relaxation after testing the ankle jerk reflex is a characteristic sign of hypothyroidism and is associated with the severity of the hormone deficit.³²

Myxedema coma

Myxedema coma is a rare but life-threatening state of extreme hypothyroidism. It may occur in those with established hypothyroidism when they develop an acute illness. Myxedema coma can be the first presentation of hypothyroidism. People with myxedema coma typically have a low body temperature without shivering, confusion, a slow heart rate and reduced breathing effort. There may be physical signs suggestive of hypothyroidism, such as skin changes or enlargement of the tongue.³³

Pregnancy

Main article: Thyroid disease in women

Hypothyroidism when untreated may lead to infertility and an increased risk of miscarriage or infant death around the time of birth, mostly in severe cases of hypothyroidism.³⁴³⁵ Women are affected by hypothyroidism in 0.3–0.5% of pregnancies.³⁶ Subclinical hypothyroidism during pregnancy is associated with birth of the baby before 37 weeks of pregnancy.³⁷

Children

Newborn children with hypothyroidism may have normal birth weight and height (although the head may be larger than expected and the posterior fontanelle may be open). Some may have drowsiness, decreased muscle tone, poor weight gain, a hoarse-sounding cry, feeding difficulties, constipation, an enlarged tongue, umbilical hernia, dry skin, a decreased body temperature, and jaundice.³⁸ A goiter is rare, although it may develop later in children who have a thyroid gland that does not produce functioning thyroid hormone.³⁹ A goiter may also develop in children growing up in areas with iodine deficiency.⁴⁰ Normal growth and development may be delayed, and not treating infants may lead to an intellectual impairment (IQ 6–15 points lower in severe cases). Other problems include the following: difficulty with large scale and fine motor skills and coordination, reduced muscle tone, squinting, decreased attention span, and delayed speaking.⁴¹ Tooth eruption may be delayed.⁴²

In older children and adolescents, the symptoms of hypothyroidism may include fatigue, cold intolerance, sleepiness, muscle weakness, constipation, a delay in growth, overweight for height, pallor, coarse and thick skin, increased body hair, irregular menstrual cycles in girls, and delayed puberty. Signs may include delayed relaxation of the ankle reflex and a slow heartbeat.⁴³ A goiter may be present with a completely enlarged thyroid gland;⁴⁴ sometimes only part of the thyroid is enlarged and it can be knobby.⁴⁵

Causes

Hypothyroidism is caused by inadequate function of the gland itself (primary hypothyroidism), inadequate stimulation by thyroid-stimulating hormone from the pituitary gland (secondary hypothyroidism), or inadequate release of thyrotropin-releasing hormone from the brain's hypothalamus (tertiary hypothyroidism).⁴⁶⁴⁷ Primary hypothyroidism is about a thousandfold more common than central hypothyroidism.⁴⁸ Central hypothyroidism is the name used for secondary and tertiary hypothyroidism since the hypothalamus and pituitary gland are at the center of thyroid hormone control.

Iodine deficiency is the most common cause of primary hypothyroidism and endemic goiter worldwide.⁴⁹⁵⁰ In areas of the world with sufficient dietary iodine, hypothyroidism is most commonly caused by the autoimmune disease Hashimoto's thyroiditis (chronic autoimmune thyroiditis).⁵¹⁵² Hashimoto's may be associated with a goiter. It is characterized by infiltration of the thyroid gland with T lymphocytes and autoantibodies against specific thyroid antigens such as thyroid peroxidase, thyroglobulin and the TSH receptor.⁵³

After women give birth, about 5% develop postpartum thyroiditis which can occur up to nine months afterwards.⁵⁴ This is characterized by a short period of hyperthyroidism followed by a period of hypothyroidism; 20–40% remain permanently hypothyroid.⁵⁵

Autoimmune thyroiditis (Hashimoto's) is associated with other immune-mediated diseases such as diabetes mellitus type 1, pernicious anemia, myasthenia gravis, celiac disease, rheumatoid arthritis and systemic lupus erythematosus.⁵⁶ It may occur as part of autoimmune polyendocrine syndrome (type 1 and type 2).⁵⁷

Iatrogenic hypothyroidism can be surgical (a result of thyroidectomy, usually for thyroid nodules or cancer) or following radioiodine ablation (usually for Graves' disease).

Pathophysiology

Thyroid hormone is required for the normal functioning of numerous tissues in the body. In healthy individuals, the thyroid gland predominantly secretes thyroxine (T4), which is converted into triiodothyronine (T3) in other organs by the selenium-dependent enzyme iodothyronine deiodinase.⁶² Triiodothyronine binds to the thyroid hormone receptor in the nucleus of cells, where it stimulates the turning on of particular genes and the production of specific proteins.⁶³ Additionally, the hormone binds to integrin αvβ3 on the cell membrane, thereby stimulating the sodium–hydrogen antiporter and processes such as formation of blood vessels and cell growth.⁶⁴ In blood, almost all thyroid hormone (99.97%) are bound to plasma proteins such as thyroxine-binding globulin; only the free unbound thyroid hormone is biologically active.⁶⁵

Electrocardiograms are abnormal in both primary overt hypothyroidism and subclinical hypothyroidism.⁶⁶ T3 and TSH are essential for the regulation of cardiac electrical activity.⁶⁷ Prolonged ventricular repolarization and atrial fibrillation are often seen in hypothyroidism.⁶⁸

The thyroid gland is the only source of thyroid hormone in the body; the process requires iodine and the amino acid tyrosine. The gland takes up iodine in the bloodstream and incorporates it into thyroglobulin molecules. The process is controlled by the thyroid-stimulating hormone (TSH, thyrotropin), which is secreted by the pituitary. Not enough iodine, or not enough TSH, can decrease thyroid hormone production.⁶⁹

The hypothalamic–pituitary–thyroid axis plays a key role in maintaining thyroid hormone levels within normal limits. Production of TSH by the anterior pituitary gland is stimulated in turn by thyrotropin-releasing hormone (TRH), released from the hypothalamus. Production of TSH and TRH is decreased by thyroxine by a negative feedback process. Not enough TRH, which is uncommon, can lead to insufficient TSH release and therefore insufficient thyroid hormone production.⁷⁰

Pregnancy leads to marked changes in thyroid hormone physiology. The gland increases in size by 10%, thyroxine production increases by 50%, and iodine requirements increase. Many women have normal thyroid function but have immunological evidence of thyroid autoimmunity (as evidenced by autoantibodies) or are iodine deficient, and develop evidence of hypothyroidism before or after giving birth.⁷¹

Diagnosis

See also: Thyroid function tests

Laboratory testing of thyroid stimulating hormone (TSH) levels in the blood is considered the best initial test for hypothyroidism; a second TSH level is often obtained several weeks later for confirmation.⁷² Levels may be abnormal in the context of other illnesses, and TSH testing in hospitalized people is discouraged unless thyroid dysfunction is strongly suspected⁷³ as the cause of the acute illness.⁷⁴ An elevated TSH level indicates that the thyroid gland is not producing enough thyroid hormone, and free T4 levels are then often obtained.⁷⁵⁷⁶⁷⁷ Measuring T3 in the assessment for hypothyroidism is discouraged by the American Association of Clinical Endocrinologists (AACE) and National Institute for Health and Care Excellence (NICE).⁷⁸ NICE recommends routine T4 testing in children where clinically indicated, and in adults only if central hypothyroidism is suspected or the TSH is abnormal.⁷⁹ There are several symptom rating scales for hypothyroidism; they provide a degree of objectivity but have limited use for diagnosis.⁸⁰

Many cases of hypothyroidism are associated with mild elevations in creatine kinase and liver enzymes in the blood. They typically return to normal when hypothyroidism has been fully treated.⁸¹ Levels of cholesterol, low-density lipoprotein and lipoprotein (a) can be elevated;⁸² the impact of subclinical hypothyroidism on lipid parameters is less well-defined.⁸³

Very severe hypothyroidism and myxedema coma are characteristically associated with low sodium levels in the blood together with elevations in antidiuretic hormone, as well as acute worsening of kidney function due to several causes.⁸⁴ For most causes, however, it is unclear if the relationship is causal.⁸⁵

A diagnosis of hypothyroidism without any lumps or masses felt within the thyroid gland does not require thyroid imaging; however, if the thyroid feels abnormal, diagnostic imaging is then recommended.⁸⁶ The presence of antibodies against thyroid peroxidase (TPO) makes it more likely that thyroid nodules are caused by autoimmune thyroiditis, but if there is any doubt, a needle biopsy may be required.⁸⁷

Central

If the TSH level is normal or low and serum free T4 levels are low, this is suggestive of central hypothyroidism (not enough TSH or TRH secretion by the pituitary gland or hypothalamus, respectively). There may be other features of hypopituitarism, such as menstrual cycle abnormalities and adrenal insufficiency. There might also be symptoms of a pituitary mass such as headaches and vision changes. Central hypothyroidism should be investigated further to determine the underlying cause.⁸⁸⁸⁹

Overt

In overt primary hypothyroidism, TSH levels are high and T4 levels are low. Overt hypothyroidism may also be diagnosed in those who have a TSH on multiple occasions of greater than 5mIU/L, appropriate symptoms, and only a borderline low T4.⁹⁰ It may also be diagnosed in those with a TSH of greater than 10mIU/L.⁹¹

Subclinical

Subclinical hypothyroidism is a biochemical diagnosis characterized by an elevated serum TSH level, but with a normal serum free thyroxine level.⁹²⁹³⁹⁴ The incidence of subclinical hypothyroidism is estimated to be 3-15% and a higher incidence is seen in elderly people, females and those with lower iodine levels.⁹⁵ Subclinical hypothyroidism is most commonly caused by autoimmune thyroid diseases, especially Hashimoto's thyroiditis.⁹⁶ The presentation of subclinical hypothyroidism is variable and classic signs and symptoms of hypothyroidism may not be observed.⁹⁷ Of people with subclinical hypothyroidism, a proportion will develop overt hypothyroidism each year. In those with detectable antibodies against thyroid peroxidase (TPO), this occurs in 4.3%, while in those with no detectable antibodies, this occurs in 2.6%.⁹⁸ In addition to detectable anti-TPO antibodies, other risk factors for conversion from subclinical hypothyroidism to overt hypothyroidism include female sex or in those with higher TSH levels or lower level of normal free T4 levels.⁹⁹ Those with subclinical hypothyroidism and detectable anti-TPO antibodies who do not require treatment should have repeat thyroid function tested more frequently (e.g. every 6 months) compared with those who do not have antibodies.¹⁰⁰¹⁰¹

Pregnancy

During pregnancy, the thyroid gland must produce 50% more thyroid hormone to provide enough thyroid hormone for the developing fetus and the expectant mother.¹⁰² In pregnancy, free thyroxine levels may be lower than anticipated due to increased binding to thyroid binding globulin and decreased binding to albumin. They should either be corrected for the stage of pregnancy,¹⁰³ or total thyroxine levels should be used instead for diagnosis.¹⁰⁴ TSH values may also be lower than normal (particularly in the first trimester) and the normal range should be adjusted for the stage of pregnancy.¹⁰⁵¹⁰⁶

In pregnancy, subclinical hypothyroidism is defined as a TSH between 2.5 and 10 mIU/L with a normal thyroxine level, while those with TSH above 10 mIU/L are considered to be overtly hypothyroid even if the thyroxine level is normal.¹⁰⁷ Antibodies against TPO may be important in making treatment decisions, and should, therefore, be determined in women with abnormal thyroid function tests.¹⁰⁸ Determination of TPO antibodies may be considered as part of the assessment of recurrent miscarriage, as subtle thyroid dysfunction can be associated with pregnancy loss,¹⁰⁹ but this recommendation is not universal,¹¹⁰ and the presence of thyroid antibodies may not predict future outcomes.¹¹¹

Prevention

Hypothyroidism may be prevented in a population by adding iodine to commonly used foods. This public health measure has eliminated endemic childhood hypothyroidism in countries where it was once common. In addition to promoting the consumption of iodine-rich foods such as dairy and fish, many countries with moderate iodine deficiency have implemented universal salt iodization.¹¹² Encouraged by the World Health Organization,¹¹³ 70% of the world's population across 130 countries are receiving iodized salt. In some countries, iodized salt is added to bread.¹¹⁴ Despite this, iodine deficiency has reappeared in some Western countries due to attempts to reduce salt intake.¹¹⁵

Pregnant and breastfeeding women, who require 66% more daily iodine than non-pregnant women, may still not be getting enough iodine.¹¹⁶¹¹⁷ The World Health Organization recommends a daily intake of 250 μg for pregnant and breastfeeding women.¹¹⁸ As many women will not achieve this from dietary sources alone, the American Thyroid Association recommends a 150 μg daily supplement by mouth.¹¹⁹¹²⁰

Screening

Screening for hypothyroidism is performed in the newborn period in many countries, generally using TSH. This has led to the early identification of many cases and thus the prevention of developmental delay.¹²¹ It is the most widely used newborn screening test worldwide.¹²² While TSH-based screening will identify the most common causes, the addition of T4 testing is required to pick up the rarer central causes of neonatal hypothyroidism.¹²³ If T4 determination is included in the screening done at birth, this will identify cases of congenital hypothyroidism of central origin in 1:16,000 to 1:160,000 children. Considering that these children usually have other pituitary hormone deficiencies, early identification of these cases may prevent complications.¹²⁴

In adults, widespread screening of the general population is debated. Some organizations (such as the United States Preventive Services Task Force) state that evidence is insufficient to support routine screening,¹²⁵ while others (such as the American Thyroid Association) recommend either intermittent testing above a certain age in all sexes or only in women.¹²⁶ Targeted screening may be appropriate in a number of situations where hypothyroidism is common: other autoimmune diseases, a strong family history of thyroid disease, those who have received radioiodine or other radiation therapy to the neck, those who have previously undergone thyroid surgery, those with an abnormal thyroid examination, those with psychiatric disorders, people taking amiodarone or lithium, and those with a number of health conditions (such as certain heart and skin conditions).¹²⁷ Yearly thyroid function tests are recommended in people with Down syndrome, as they are at higher risk of thyroid disease.¹²⁸ Guidelines for England and Wales from the National Institute for Health and Care Excellence (NICE) recommend testing for thyroid disease in people with type 1 diabetes and new-onset atrial fibrillation, and suggests testing in those with depression or unexplained anxiety (all ages), in children with abnormal growth, or unexplained change in behavior or school performance.¹²⁹ NICE also recommends screening for celiac disease in people with a diagnosis of autoimmune thyroid disease.¹³⁰

Management

Hormone replacement

Hypothyroidism is managed by hormone substitution with a synthetic long-acting form of thyroxine, known as levothyroxine (L-thyroxine).¹³¹¹³² In young and otherwise healthy people with overt hypothyroidism, a full replacement dose (adjusted by weight) can be started immediately; in the elderly and people with heart disease a lower starting dose is recommended to prevent over supplementation and risk of complications.^133134135 Lower doses may be sufficient in those with subclinical hypothyroidism, while people with central hypothyroidism may require a higher than average dose.¹³⁶

Blood and TSH levels are monitored to help determine whether the dose is adequate. This is done 4–8 weeks after the start of treatment or a change in levothyroxine dose. Once the adequate replacement dose has been established, the tests can be repeated after 6 and then 12 months, unless there is a change in symptoms.¹³⁷ Normalization of TSH does not mean that other abnormalities associated with hypothyroidism improve entirely, such as elevated cholesterol levels.¹³⁸

In people with central hypothyroidism, TSH is not a reliable marker of hormone replacement and decisions are based mainly on the free T4 level.¹³⁹¹⁴⁰ Levothyroxine is best taken 30–60 minutes before breakfast, or four hours after food,¹⁴¹ as certain substances such as food and calcium can inhibit the absorption of levothyroxine.¹⁴² There is no direct way of increasing thyroid hormone secretion by the thyroid gland.¹⁴³

Liothyronine

Treatment with liothyronine (synthetic T3) alone has not received enough study to make a recommendation as to its use; due to its shorter half-life it would need to be taken more often than levothyroxine.¹⁴⁴

Adding liothyronine to levothyroxine has been suggested as a measure to provide better symptom control, but this has not been confirmed by studies.^145146147 In 2007, the British Thyroid Association stated that combined T4 and T3 therapy carried a higher rate of side effects and no benefit over T4 alone.¹⁴⁸¹⁴⁹ Similarly, American guidelines discourage combination therapy due to a lack of evidence, although they acknowledge that some people feel better when receiving combination therapy.¹⁵⁰ Guidelines by National Institute for Health and Care Excellence (NICE) discourage liothyronine.¹⁵¹

People with hypothyroidism who do not feel well despite optimal levothyroxine dosing may request adjunctive treatment with liothyronine. A 2012 guideline from the European Thyroid Association recommends that support should be offered concerning the chronic nature of the disease and that other causes of the symptoms should be excluded. The addition of liothyronine should be regarded as experimental, initially only for a trial period of 3 months, and in a set ratio to the current dose of levothyroxine.¹⁵² The guideline explicitly aims to enhance the safety of this approach and to counter its indiscriminate use.¹⁵³ A 2014 guideline from the American Thyroid Association recommends against the use of liothyronine.¹⁵⁴

Desiccated animal thyroid

Desiccated thyroid extract is an animal-based thyroid gland extract,¹⁵⁵ most commonly from pigs. It is a combination therapy, containing forms of T4 and T3.¹⁵⁶ It also contains calcitonin (a hormone produced in the thyroid gland involved in the regulation of calcium levels), T1 and T2; these are not present in synthetic hormone medication.¹⁵⁷ This extract was once a mainstream hypothyroidism treatment, but has been disregarded since the 1970s and its use is unsupported by evidence;¹⁵⁸¹⁵⁹ British Thyroid Association and American professional guidelines discourage its use,^160161162 as does NICE.¹⁶³

Subclinical hypothyroidism

There is no evidence of a benefit from treating subclinical hypothyroidism in those who are not pregnant, and there are potential risks of unnecessary overtreatment.¹⁶⁴ Untreated subclinical hypothyroidism may be associated with a modest increase in the risk of coronary artery disease when the TSH is over 10 mIU/L.¹⁶⁵¹⁶⁶ There may be an increased risk for cardiovascular death.¹⁶⁷ A 2007 review found no benefit of thyroid hormone replacement except for "some parameters of lipid profiles and left ventricular function".¹⁶⁸ There is no association between subclinical hypothyroidism and an increased risk of bone fractures,¹⁶⁹ nor is there a link with cognitive decline.¹⁷⁰

American guidelines recommend that treatment should be considered in people with symptoms of hypothyroidism, detectable antibodies against thyroid peroxidase, a history of heart disease, or are at an increased risk for heart disease if the TSH is elevated but below 10 mIU/L.¹⁷¹ American guidelines further recommend universal treatment (independent of risk factors) in those with TSH levels that are markedly elevated; above 10 mIU/L because of an increased risk of heart failure or death due to cardiovascular disease.¹⁷²¹⁷³ NICE recommends that those with a TSH above 10 mIU/L should be treated in the same way as overt hypothyroidism. Those with an elevated TSH but below 10 mIU/L who have symptoms suggestive of hypothyroidism should have a trial of treatment but intend to stop this if the symptoms persist despite normalization of the TSH.¹⁷⁴

Myxedema coma

Myxedema coma or severe decompensated hypothyroidism usually requires admission to the intensive care, close observation and treatment of abnormalities in breathing, temperature control, blood pressure, and sodium levels. Mechanical ventilation may be required, as well as fluid replacement, vasopressor agents, careful rewarming, and corticosteroids (for possible adrenal insufficiency which can occur together with hypothyroidism). Careful correction of low sodium levels may be achieved with hypertonic saline solutions or vasopressin receptor antagonists.¹⁷⁵ For rapid treatment of hypothyroidism, levothyroxine or liothyronine may be administered intravenously, particularly if the level of consciousness is too low to be able to safely swallow medication.¹⁷⁶ While administration through a nasogastric tube is possible, this may be unsafe and is discouraged.¹⁷⁷

Pregnancy

In women with known hypothyroidism who become pregnant, it is recommended that serum TSH levels are closely monitored. Levothyroxine should be used to keep TSH levels within the normal range for that trimester. The first-trimester normal range is below 2.5 mIU/L and the second and third trimesters normal range is below 3.0 mIU/L.¹⁷⁸¹⁷⁹ Measurement of free T4 in pregnancy is not recommended due to changes in levels of serum protein binding. Similarly to TSH, the thyroxine results should be interpreted according to the appropriate reference range for that stage of pregnancy.¹⁸⁰ The levothyroxine dose often needs to be increased after pregnancy is confirmed,^181182183 although this is based on limited evidence and some recommend that it is not always required; decisions may need to based on TSH levels.¹⁸⁴

Women with anti-TPO antibodies who are trying to become pregnant (naturally or by assisted means) may require thyroid hormone supplementation even if the TSH level is normal. This is particularly true if they have had previous miscarriages or have been hypothyroid in the past.¹⁸⁵ Supplementary levothyroxine may reduce the risk of preterm birth and possibly miscarriage.¹⁸⁶ The recommendation is stronger in pregnant women with subclinical hypothyroidism (defined as TSH 2.5–10 mIU/L) who are anti-TPO positive, in view of the risk of overt hypothyroidism. If a decision is made not to treat, close monitoring of the thyroid function (every 4 weeks in the first 20 weeks of pregnancy) is recommended.¹⁸⁷¹⁸⁸ If anti-TPO is not positive, treatment for subclinical hypothyroidism is not currently recommended.¹⁸⁹ It has been suggested that many of the aforementioned recommendations could lead to unnecessary treatment, in the sense that the TSH cutoff levels may be too restrictive in some ethnic groups; there may be little benefit from treatment of subclinical hypothyroidism in certain cases.¹⁹⁰ Treatment for subclinical hypothyroidism in pregnancy is not conclusively shown to decrease the incidence of miscarriage.^191192193

Alternative medicine

The effectiveness and safety of using Chinese herbal medicines to treat hypothyroidism is not known.¹⁹⁴

Epidemiology

Hypothyroidism is the most frequent endocrine disorder.¹⁹⁵ Worldwide about one billion people are estimated to be iodine deficient; however, it is unknown how often this results in hypothyroidism.¹⁹⁶ In large population-based studies in Western countries with sufficient dietary iodine, 0.3–0.4% of the population have overt hypothyroidism. A larger proportion, 4.3–8.5%, have subclinical hypothyroidism.¹⁹⁷ Undiagnosed hypothyroidism is estimated to affect about 4–7% of community-derived populations in the US and Europe.¹⁹⁸ Of people with subclinical hypothyroidism, 80% have a TSH level below the 10 mIU/L mark regarded as the threshold for treatment.¹⁹⁹ Children with subclinical hypothyroidism often return to normal thyroid function, and a small proportion develops overt hypothyroidism (as predicted by evolving antibody and TSH levels, the presence of celiac disease, and the presence of a goiter).²⁰⁰

Women are more likely to develop hypothyroidism than men. In population-based studies, women were seven times more likely than men to have TSH levels above 10 mU/L.²⁰¹ 2–4% of people with subclinical hypothyroidism will progress to overt hypothyroidism each year. The risk is higher in those with antibodies against thyroid peroxidase.²⁰²²⁰³ Subclinical hypothyroidism is estimated to affect approximately 2% of children; in adults, subclinical hypothyroidism is more common in the elderly, and in White people.²⁰⁴ There is a much higher rate of thyroid disorders, the most common of which is hypothyroidism, in individuals with Down syndrome²⁰⁵²⁰⁶ and Turner syndrome.²⁰⁷

Very severe hypothyroidism and myxedema coma are rare, with it estimated to occur in 0.22 per million people a year.²⁰⁸ The majority of cases occur in women over 60 years of age, although it may happen in all age groups.²⁰⁹

Most hypothyroidism is primary in nature. Central/secondary hypothyroidism affects 1:20,000 to 1:80,000 of the population or about one out of every thousand people with hypothyroidism.²¹⁰

History

In 1811, Bernard Courtois discovered iodine was present in seaweed, and iodine intake was linked with goiter size in 1820 by Jean-Francois Coindet.²¹¹ Gaspard Adolphe Chatin proposed in 1852 that endemic goiter was the result of not enough iodine intake, and Eugen Baumann demonstrated iodine in thyroid tissue in 1896.²¹²

The first cases of myxedema were recognized in the mid-19th century (the 1870s), but its connection to the thyroid was not discovered until the 1880s when myxedema was observed in people following the removal of the thyroid gland (thyroidectomy).²¹³ The link was further confirmed in the late 19th century when people and animals who had had their thyroid removed showed improvement in symptoms with transplantation of animal thyroid tissue.²¹⁴ The severity of myxedema, and its associated risk of mortality and complications, created interest in discovering effective treatments for hypothyroidism.²¹⁵ Transplantation of thyroid tissue demonstrated some efficacy, but recurrences of hypothyroidism was relatively common, and sometimes required multiple repeat transplantations of thyroid tissue.²¹⁶

In 1891, the English physician George Redmayne Murray introduced subcutaneously injected sheep thyroid extract,²¹⁷ followed shortly after by an oral formulation.²¹⁸²¹⁹ Purified thyroxine was introduced in 1914 and in the 1930s synthetic thyroxine became available, although desiccated animal thyroid extract remained widely used. Liothyronine was identified in 1952.²²⁰

Early attempts at titrating therapy for hypothyroidism proved difficult. After hypothyroidism was found to cause a lower basal metabolic rate, this was used as a marker to guide adjustments in therapy in the early 20th century (around 1915).²²¹ However, a low basal metabolic rate was known to be non-specific, also present in malnutrition.²²² The first laboratory test to help assess thyroid status was the serum protein-bound iodine, which came into use around the 1950s.

In 1971, the thyroid stimulating hormone (TSH) radioimmunoassay was developed, which was the most specific marker for assessing thyroid status in patients.²²³ Many people who were being treated based on basal metabolic rate, minimizing hypothyroid symptoms, or based on serum protein-bound iodine, were found to have excessive thyroid hormone.²²⁴ The following year, in 1972, a T3 radioimmunoassay was developed, and in 1974, a T4 radioimmunoassay was developed.²²⁵

Other animals

Main article: Hypothyroidism in dogs

In veterinary practice, dogs are the species most commonly affected by hypothyroidism. The majority of cases occur as a result of primary hypothyroidism, of which two types are recognized: lymphocytic thyroiditis, which is probably immune-driven and leads to destruction and fibrosis of the thyroid gland, and idiopathic atrophy, which leads to the gradual replacement of the gland by fatty tissue.²²⁶²²⁷ There is often lethargy, cold intolerance, exercise intolerance, and weight gain. Furthermore, skin changes and fertility problems are seen in dogs with hypothyroidism, as well as many other symptoms.²²⁸ The signs of myxedema can be seen in dogs, with prominence of skin folds on the forehead, and cases of myxedema coma are encountered.²²⁹ The diagnosis can be confirmed by a blood test, as the clinical impression alone may lead to overdiagnosis.²³⁰²³¹ Lymphocytic thyroiditis is associated with detectable antibodies against thyroglobulin, although they typically become undetectable in advanced disease.²³² Treatment is with thyroid hormone replacement.²³³

Other species that are less commonly affected include cats and horses, as well as other large domestic animals. In cats, hypothyroidism is usually the result of other medical treatments such as surgery or radiation. In young horses, congenital hypothyroidism has been reported predominantly in Western Canada and has been linked with the mother's diet.²³⁴

External links

• "Hypothyroidism information for patients". American Thyroid Association.

References

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