NOD1

Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a <a href="/facts/Protein/Jxmagu3E">protein</a> receptor that in humans is encoded by the NOD1 <a href="/facts/Gene/e1swwPY6">gene</a>. It recognizes bacterial molecules and stimulates an immune reaction.
NOD1 protein contains a <a href="/facts/Caspase_recruitment_domain/ySJupuCo">caspase recruitment domain</a> (CARD). NOD1 is a member of <a href="/facts/NOD-like_receptor/2qwEHM7U">NOD-like receptor</a> protein family and is a close relative of <a href="/facts/NOD2/zhx0pnLD">NOD2</a>. NOD1 is an intracellular <a href="/facts/Pattern_recognition_receptor/ItopNrK0">pattern recognition receptor</a>, which is similar in structure to resistant proteins of plants, and mediates <a href="/facts/Innate_immune_system/lz4BpSQI">innate</a> and <a href="/facts/Adaptive_immune_system/bc7zT1Jo">acquired immunity</a> by recognizing molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety, including bacterial <a href="/facts/Peptidoglycan/lflRRUNw">peptidoglycan</a>. Nod1 interacts with <a href="/facts/RIPK2/T9Port4U">RIPK2</a> through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor <a href="/facts/NF-%CE%BAB/qcpt5vuQ">NF-κB</a>.

NOD1 open-in-new

NOD1