The scratch reflex is an automatic response to the activation of sensory neurons located on the surface of the body. Sensory neurons can be activated via stimulation, such as a parasite on the body, but can also be activated by responding to a chemical stimulus that produces an itching sensation. During a scratch reflex, a limb reaches toward and rubs against the site on the body surface that has been stimulated. The scratch reflex has been extensively studied to understand the functioning of neural networks in vertebrates. Despite decades of research, key aspects of the scratch reflex are still unknown, such as the neural mechanisms by which the reflex is terminated.