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Reference.org
Pathophysiology of nerve entrapment
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<p><a href="/facts/Nerve_compression_syndrome/wWVpnPFV">Nerve entrapment</a> involves a cascade of physiological changes caused by compression and tension. Some of these changes are irreversible. The magnitude and duration of the forces determines the extent of injury. In the acute form, mechanical injury and metabolic blocks impede nerve function. In the chronic form, there is a sequence of changes starting with a breakdown of the blood-nerve-barrier, followed by <a href="/facts/Edema/Q6MI3KdH">edema</a> with connective tissue changes, followed by diffuse <a href="/facts/Demyelinating_disease/NAaGAHPV">demyelination</a>, and finally followed by axonmetesis. The injury will often be a mixed lesion where mild/moderate compression is a combination of a metabolic block and <a href="/facts/Neurapraxia/xgsMSGlu">neuropraxia</a>, while severe compression combines elements of neuropraxia and axonmetesis. </p>