Angiotensin-converting enzyme

<p>Angiotensin-converting enzyme (<a href="/facts/Enzyme_Commission_number/Y5GNLRKX">EC</a> <a href="https://enzyme.expasy.org/EC/3.4.15.1">3.4.15.1</a>), or ACE, is a central component of the <a href="/facts/Renin%25E2%2580%2593angiotensin_system/9XLt8PQL">renin–angiotensin system</a> (RAS), which controls blood pressure by regulating the volume of fluids in the body. It converts the hormone <a href="/facts/Angiotensin_I/Aky7PMMX">angiotensin I</a> to the active <a href="/facts/Vasoconstriction/9hdY0aR2">vasoconstrictor</a> <a href="/facts/Angiotensin_II/Aky7PMMX">angiotensin II</a>. Therefore, ACE indirectly increases blood pressure by causing blood vessels to constrict. <a href="/facts/ACE_inhibitor/cHT1Yxub">ACE inhibitors</a> are widely used as pharmaceutical drugs for treatment of <a href="/facts/Cardiovascular_disease/HD420nMv">cardiovascular diseases</a>.
</p><p>Other lesser known functions of ACE are degradation of <a href="/facts/Bradykinin/68Ry9vTk">bradykinin</a>, <a href="/facts/Substance_P/BySc2oeD">substance P</a> and <a href="/facts/Amyloid_beta/QkXy91f9">amyloid beta-protein</a>.
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Angiotensin-converting enzyme open-in-new

Angiotensin-converting enzyme