PyAOP reagent

<p>PyAOP ((7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate) is a reagent used to prepare <a href="/facts/Amide/C6kCzYEA">amides</a> from <a href="/facts/Carboxylic_acid/U4xuMosy">carboxylic acids</a> and <a href="/facts/Amine/JvfYJfP6">amines</a> in the context of <a href="/facts/Peptide_synthesis/Upd4aqKa">peptide synthesis</a>. It can be prepared from <a href="/facts/1-Hydroxy-7-azabenzotriazole/tRuwUaoK">1-hydroxy-7-azabenzotriazole</a> (HOAt) and a <a href="/facts/Phosphonium/uS2PCt7X">chlorophosphonium</a> reagent under basic conditions. It is a derivative of the HOAt family of amide bond forming reagents. It is preferred over <a href="/facts/HATU/cQXjCMyI">HATU</a>, because it does not engage in side reactions with the N-terminus of the peptide. Compared to the <a href="/facts/HOBt/heGstL97">HOBt</a>-containing analog <a href="/facts/PyBOP/m98V8Q1q">PyBOP</a>, PyAOP is more reactive due to the additional nitrogen in the fused <a href="/facts/Pyridine/X817hCch">pyridine</a> ring of the HOAt moiety. Thermal hazard analysis by <a href="/facts/Differential_scanning_calorimetry/Gj9u8Plc">differential scanning calorimetry (DSC)</a> shows PyAOP is potentially explosive.
</p>

PyAOP reagent open-in-new

PyAOP reagent