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Reference.org
Macrophage-1 antigen
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<p>Macrophage-1 antigen (or integrin αMβ2 or macrophage integrin or Mac-1) is a <a href="/facts/Complement_receptor/EsI570Ic">complement receptor</a> ("CR3") consisting of <a href="/facts/CD11b/SDNFWgNB">CD11b</a> (integrin αM) and <a href="/facts/CD18/gCr14tJd">CD18</a> (integrin β2). </p><p>The integrin α chain is noncovalently bound to the integrin β chain. It binds to <a href="/facts/IC3b/oD7WlMVY">iC3b</a> and can be involved in cellular adhesion, binding to the intercellular adhesion molecule-1 (<a href="/facts/ICAM-1/H2bKaUyN">ICAM-1</a>). CR3 causes <a href="/facts/Phagocytosis/eBrv2XKV">phagocytosis</a> and destruction of cells opsonized with iC3b. CR3 and CR4 are thought to exhibit overlapping functions; however, the distinct binding sites to iC3b suggests differences in their functions. Additionally, CR3 has been shown to have therapeutic promise. </p>