James P. Eisenstein (born May 15, 1952) is an American physicist. He is currently the Frank J. Roshek Professor of Physics and Applied Physics, Emeritus, at the California Institute of Technology. He received a share of the 2025 Wolf Prize in Physics for his experimental research on strongly interacting two-dimensional electron systems. He co-discovered the 5/2 filling factor state of the fractional quantum Hall effect and demonstrated the Bose–Einstein condensation of excitons in two dimensions.