The fourth season of the American television sitcom The Big Bang Theory aired on CBS from September 23, 2010 to May 19, 2011. Melissa Rauch and Mayim Bialik auditioned and were promoted to the main cast during this season as Dr. Bernadette Rostenkowski and Dr. Amy Farrah Fowler respectively.
Johnny Galecki received a nomination for the Primetime Emmy Award for Outstanding Lead Actor in a Comedy Series at the 63rd Primetime Emmy Awards for the episode "The Benefactor Factor". Jim Parsons won the same award for the episode "The Agreement Dissection".