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Cisplatin
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<p>Cisplatin is a chemical compound with <a href="/facts/Chemical_formula/hghUtthl">formula</a> <i>cis</i>-[Pt(NH3)2Cl2]. It is a <a href="/facts/Coordination_complex/1tCyeQUm">coordination complex</a> of <a href="/facts/Platinum/qJC6lQf7">platinum</a> that is used as a <a href="/facts/Chemotherapy_medication/fWTLbaUT">chemotherapy medication</a> used to treat a number of <a href="/facts/Cancers/PVW6n1D0">cancers</a>. These include <a href="/facts/Testicular_cancer/v8qGnvRm">testicular cancer</a>, <a href="/facts/Ovarian_cancer/fsWbh3Tn">ovarian cancer</a>, <a href="/facts/Cervical_cancer/99vngUyd">cervical cancer</a>, <a href="/facts/Bladder_cancer/qry4214P">bladder cancer</a>, <a href="/facts/Head_and_neck_cancer/v8T8bNs7">head and neck cancer</a>, <a href="/facts/Esophageal_cancer/vN32X3uc">esophageal cancer</a>, <a href="/facts/Lung_cancer/LHLdR454">lung cancer</a>, <a href="/facts/Mesothelioma/KmqMKqld">mesothelioma</a>, <a href="/facts/Brain_tumors/avjI5Nhm">brain tumors</a> and <a href="/facts/Neuroblastoma/nzCww7nE">neuroblastoma</a>. It is given by <a href="/facts/Intravenous/AwwuD3Nu">injection into a vein</a>. </p><p>Common side effects include <a href="/facts/Bone_marrow_suppression/NEdoL9nj">bone marrow suppression</a>, <a href="/facts/Hearing_problems/7C78RpMP">hearing problems</a> including severe hearing loss, <a href="/facts/Nephrotoxicity/QaWn5pwB">kidney damage</a>, and <a href="/facts/Vomiting/R2vQkHqV">vomiting</a>. Other serious side effects include numbness, trouble walking, <a href="/facts/Allergic_reactions/dYAVosh8">allergic reactions</a>, <a href="/facts/Electrolyte_problems/mmb7W3A0">electrolyte problems</a>, and <a href="/facts/Heart_disease/HD420nMv">heart disease</a>. Use during pregnancy can cause harm to the developing fetus. Cisplatin is in the <a href="/facts/Platinum-based_antineoplastic/eg5qQtd7">platinum-based antineoplastic</a> family of medications. It works in part by binding to DNA and inhibiting <a href="/facts/DNA_replication/wrU6RuR3">its replication</a>. </p><p>Cisplatin was first reported in 1845 and licensed for medical use in 1978 and 1979. It is on the <a href="/facts/WHO_Model_List_of_Essential_Medicines/6kmu81Xm">World Health Organization's List of Essential Medicines</a>. </p>