Guaifenesin/codeine is a fixed-dose combination cold medicine used for the treatment of cough. It contains guaifenesin, an expectorant; and codeine, as the phosphate, an opioid antitussive. It is taken by mouth.
It was approved for medical use in the United States in 2006. In 2022, it was the 272nd most commonly prescribed medication in the United States, with more than 800,000 prescriptions.