The group stage of the 2010–11 UEFA Champions League featured 32 teams: the 22 automatic qualifiers and the 10 winners of the play-off round (five through the Champions Path, five through the Non-Champions Path).
The teams were drawn into eight groups of four, and played each other home-and-away in a round-robin format. The matchdays were 14–15 September, 28–29 September, 19–20 October, 2–3 November, 23–24 November, and 7–8 December 2010.
The top two teams in each group advanced to the first knockout round, while the third-placed teams dropped down to the Europa League round of 32.
Partizan and Žilina became only the eleventh and twelfth teams in UEFA Champions League history to lose all six group stage matches.