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Reference.org
Molecular modification
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<p>Molecular modification is chemical alteration of a known and previously characterized <a href="/facts/Lead_compound/5wFoEqmS">lead compound</a> for the purpose of enhancing its usefulness as a <a href="/facts/Drug/FFFUI9n4">drug</a>. This could mean enhancing its specificity for a particular body target site, increasing its <a href="/facts/Potency_(pharmacology)/D38FDyPh">potency</a>, improving its rate and extent of <a href="/facts/Absorption_(pharmacokinetics)/LCezQPJK">absorption</a>, modifying to advantage its time course in the body, reducing its <a href="/facts/Toxicity/qa96rs60">toxicity</a>, changing its <a href="/facts/Physical_property/ujcMUceW">physical</a> or <a href="/facts/Chemical_property/uMVxKspS">chemical properties</a> (like <a href="/facts/Solubility/kLE9h3Jb">solubility</a>) to provide desired features. </p>