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MUSCLE (alignment software)
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<p>MUltiple Sequence Comparison by Log-Expectation (MUSCLE) is a computer <a href="/facts/Software/RP79lVSW">software</a> for <a href="/facts/Multiple_sequence_alignment/en7c7SQs">multiple sequence alignment</a> of <a href="/facts/Protein/Jxmagu3E">protein</a> and <a href="/facts/Nucleotide/pQKEwlJI">nucleotide</a> sequences. It is <a href="/facts/Software_license/7enfIqhL">licensed</a> as <a href="/facts/Public_domain/YWKMDKw4">public domain</a>. The method was published by Robert C. Edgar in two papers in 2004. The first paper, published in <i><a href="/facts/Nucleic_Acids_Research/0e1akdxA">Nucleic Acids Research</a></i>, introduced the sequence alignment algorithm. The second paper, published in <i><a href="/facts/BMC_Bioinformatics/KLeGLdn6">BMC Bioinformatics</a></i>, presented more technical details. </p>