Ga-68-Trivehexin

<p>68Ga-Trivehexin is a <a href="/facts/Radioactive_tracer/0210Jncn">radiotracer</a> for <a href="/facts/Positron_emission_tomography/5SmcW6qz">positron emission tomography (PET)</a>, obtained by <a href="/facts/Isotopic_labeling/Sqtr7c0G">labeling</a> the <a href="/facts/Peptide/C4ltc7UG">peptide</a> <a href="/facts/Bioconjugation/G2xbkKA4">conjugate</a> Trivehexin with the <a href="/facts/Positron/HgV4zBzA">positron</a> <a href="/facts/Beta_decay/vxTBlckp">emitting</a> <a href="/facts/Radionuclide/5WpCfbdq">radionuclide</a> <a href="/facts/Gallium-68_generator/pNaEN1BG">gallium-68 (68Ga)</a>. 68Ga-Trivehexin targets (i.e., binds to) the <a href="/facts/Cell_surface_receptor/0YGSjDdL">cell surface receptor</a> <a href="/facts/Integrin_beta_6/HVMFE7Wd">αvβ6-integrin</a> and accumulates in αvβ6-integrin-abundant tissues after <a href="/facts/Intravenous_therapy/AwwuD3Nu">intravenous</a> (i.v.) application. 68Ga-Trivehexin is thus applied for <a href="/facts/Positron_emission_tomography/5SmcW6qz">PET</a> <a href="/facts/Medical_imaging/pL6JyJEp">imaging</a> of <a href="/facts/Disease/55eeQlGL">medical conditions</a> associated with elevated αvβ6-integrin <a href="/facts/Gene_expression/alCPohLR">expression</a>.
</p><p>αvβ6-Integrin, the biological target of 68Ga-Trivehexin, is a <a href="/facts/Protein_dimer/c8LwFJPG">heterodimeric</a> <a href="/facts/Transmembrane_protein/0vQH5HrM">transmembrane</a> <a href="/facts/Cell_adhesion_molecule/84EkpbAb">cell adhesion receptor</a> whose primary natural <a href="/facts/Ligand_(biochemistry)/44QLL4eU">ligand</a> is latency associated peptide (LAP) in its <a href="/facts/Protein_complex/GW11Ee34">complex</a> with <a href="/facts/TGF_beta_1/tL0UUuFC">transforming growth factor beta 1 (TGF-β1)</a>. Binding of αvβ6-integrin to LAP releases and thus, activates TGF-β1. In <a href="/facts/Cancer_staging/d2cFsCtq">early-stage</a> <a href="/facts/Cancer/PVW6n1D0">cancer</a>, TGF-β1 acts as a tumor suppressor but can turn into a <a href="/facts/Tumor_promotion/YRIoXPUx">tumor promoter</a> as cancers develop, and furthermore induces <a href="/facts/Fibrosis/VVSmVgr3">fibrosis</a>, particularly of the <a href="/facts/Pulmonary_fibrosis/9RVcVylE">lung</a>. As the likely most important activator of TGF-β1, αvβ6-integrin is often found <a href="/facts/Gene_expression/alCPohLR">overexpressed</a> in tumors and fibrosis, which is why 68Ga-Trivehexin PET <a href="/facts/Medical_imaging/pL6JyJEp">imaging</a> is primarily relevant in this medical context.
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Ga-68-Trivehexin open-in-new

Ga-68-Trivehexin