Schotten–Baumann reaction

The Schotten–Baumann reaction is a method to synthesize <a href="/facts/Amide/C6kCzYEA">amides</a> from <a href="/facts/Amine/SN7W44fv">amines</a> and <a href="/facts/Acid_chloride/R4ppUXre">acid chlorides</a>:

Schotten–Baumann reaction conditions can also refer to the formation of <a href="/facts/Ester/FoUAIIw4">esters</a> by reaction of a <a href="/facts/Acyl_chloride/R4ppUXre">acyl chloride</a> and a primary or secondary alcohol. The reaction was first described in 1883 by <a href="/facts/Germany/paluuWBX">German</a> <a href="/facts/Chemist/N09K7Bdm">chemists</a> <a href="/facts/Carl_Schotten/jDxJN7vN">Carl Schotten</a> and <a href="/facts/Eugen_Baumann/XWubdWvz">Eugen Baumann</a>.
The name "Schotten–Baumann reaction conditions" often indicate the use of a two-phase solvent system, consisting of water and an organic solvent. The base in the water phase neutralizes the acid generated by the reaction while the starting materials and product remain in the organic phase, often <a href="/facts/Dichloromethane/mHyeTD2D">dichloromethane</a> or <a href="/facts/Diethyl_ether/Ep20vEdj">diethyl ether</a>.

Schotten–Baumann reaction open-in-new

Schotten–Baumann reaction