Tropomyosin receptor kinase C

Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a <a href="/facts/Protein/Jxmagu3E">protein</a> that in humans is encoded by the NTRK3 <a href="/facts/Gene/e1swwPY6">gene</a>.
TrkC is the high affinity <a href="/facts/Catalytic_receptor/mE6dEy6k">catalytic receptor</a> for the <a href="/facts/Neurotrophin/NwuESuUa">neurotrophin</a> <a href="/facts/NT-3/gED8r8C9">NT-3</a> (<a href="/facts/Neurotrophin-3/gED8r8C9">neurotrophin-3</a>). As such, TrkC mediates the multiple effects of this <a href="/facts/Neurotrophic_factor/bJNG05TQ">neurotrophic factor</a>, which includes neuronal differentiation and survival.
The TrkC receptor is part of the large family of <a href="/facts/Receptor_tyrosine_kinases/1oNWIdV8">receptor tyrosine kinases</a>. A "tyrosine <a href="/facts/Kinase/dhlHpjnD">kinase</a>" is an enzyme which is capable of adding a phosphate group to the certain tyrosines on target proteins, or "substrates". A <a href="/facts/Receptor_tyrosine_kinase/1oNWIdV8">receptor tyrosine kinase</a> is a "tyrosine kinase" which is located at the cellular membrane, and is activated by binding of a <a href="/facts/Ligand/6etB3qeW">ligand</a> via its extracellular domain. Other example of tyrosine kinase receptors include the <a href="/facts/Insulin_receptor/PCEbQj6k">insulin receptor</a>, the <a href="/facts/Insulin-like_growth_factor_1_receptor/R4c7MCqp">IGF-1 receptor</a>, the <a href="/facts/MuSK_protein/Nee0RegR">MuSK protein</a> receptor, the <a href="/facts/Vascular_endothelial_growth_factor/kNDc0Xj0">vascular endothelial growth factor</a> (VEGF) receptor, etc. The "substrate" proteins which are phosphorylated by TrkC include <a href="/facts/PI3_kinase/e5rtq0VG">PI3 kinase</a>.

Tropomyosin receptor kinase C open-in-new

Tropomyosin receptor kinase C