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Armodafinil
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<p>Armodafinil, sold under the brand name Nuvigil, is a <a href="/facts/Wakefulness-promoting_agent/nNnzmhNN">wakefulness-promoting</a> <a href="/facts/Medication/h9mhwWP2">medication</a> which is used to treat <a href="/facts/Excessive_daytime_sleepiness/23kqEua3">excessive daytime sleepiness</a> associated with <a href="/facts/Obstructive_sleep_apnea/ojyjhTvz">obstructive sleep apnea</a>, <a href="/facts/Narcolepsy/YfQFgVbd">narcolepsy</a>, and <a href="/facts/Shift_work_disorder/uYB9IR9j">shift work disorder</a>. It is also used <a href="/facts/Off-label_use/0PDs5VWS">off-label</a> for certain other indications. The drug is taken <a href="/facts/Oral_administration/vNQcvLVx">by mouth</a>. </p><p><a href="/facts/Side_effect/PhuX2haY">Side effects</a> of armodafinil include <a href="/facts/Headache/mdmmC9DP">headache</a>, <a href="/facts/Nausea/dyhkcbeD">nausea</a>, <a href="/facts/Dizziness/eI8UvmS5">dizziness</a>, and <a href="/facts/Insomnia/C1TnQTb2">insomnia</a>. Armodafinil acts as a <a href="/facts/Binding_selectivity/RryTsdGv">selective</a> atypical <a href="/facts/Dopamine_reuptake_inhibitor/ykjLEgzY">dopamine reuptake inhibitor</a> (DRI) and hence as an indirect <a href="/facts/Dopamine_receptor_agonist/T2dH5XUx">dopamine receptor agonist</a>. However, other <a href="/facts/Mechanism_of_action/Sjk8vfV4">mechanisms</a> might also be involved in its effects. Chemically, armodafinil is the <a href="/facts/Enantiopure_drug/D2UlXdtH">enantiopure</a> (<i>R</i>)-(–)-<a href="/facts/Enantiomer/wjPv5J3y">enantiomer</a> of the <a href="/facts/Racemic_mixture/STEagtrD">racemic mixture</a> <a href="/facts/Modafinil/u8xDYgDU">modafinil</a> (brand name Provigil). Both enantiomers of modafinil are <a href="/facts/Pharmacological_activity/jJ14jyvc">active</a> as DRIs and wakefulness-promoting agents, but armodafinil is more <a href="/facts/Potency_(pharmacology)/D38FDyPh">potent</a> and longer-acting. </p><p>Armodafinil is produced by the <a href="/facts/Pharmaceutical_company/5mCITYys">pharmaceutical company</a> <a href="/facts/Cephalon/CA9aNFCg">Cephalon</a> and was approved by the <a href="/facts/United_States/P0sCdLe5">United States</a> <a href="/facts/Food_and_Drug_Administration/rCEnh9WB">Food and Drug Administration</a> (FDA) in 2007. In 2016, the FDA granted <a href="/facts/Mylan/RxfbNYY7">Mylan</a> rights for the first <a href="/facts/Generic_drug/IF6AXDVX">generic</a> version of armodafinil to be marketed in the United States. </p>