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NMDA receptor antagonist
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<p>NMDA receptor antagonists are a class of <a href="/facts/Drugs/FFFUI9n4">drugs</a> that work to <a href="/facts/Receptor_antagonist/PuXHVNdV">antagonize</a>, or inhibit the action of, the <a href="/facts/NMDA/7jnfxMBU"><i>N</i>-Methyl-D-aspartate</a> receptor (<a href="/facts/NMDA_receptor/BqMhXEbU">NMDAR</a>). They are commonly used as <a href="/facts/Anesthetics/0xG7I2ou">anesthetics</a> for humans and animals; the state of <a href="/facts/Anesthesia/b3MKVn8E">anesthesia</a> they induce is referred to as <a href="/facts/Dissociative/5aaD39vM">dissociative</a> anesthesia. </p><p>Several synthetic opioids function additionally as NMDAR-antagonists, such as <a href="/facts/Pethidine/3U92Kb1Y">pethidine</a>, <a href="/facts/Levorphanol/PRz3R6G6">levorphanol</a>, <a href="/facts/Methadone/Gz6231sT">methadone</a>, <a href="/facts/Dextropropoxyphene/wjh8HcC2">dextropropoxyphene</a>, <a href="/facts/Tramadol/R0tYqres">tramadol</a>, and <a href="/facts/Ketobemidone/BbJAB7ov">ketobemidone</a>. </p><p>Some NMDA receptor antagonists, such as <a href="/facts/Ketamine/BtNSoqvh">ketamine</a>, <a href="/facts/Dextromethorphan/Jq9UgD4M">dextromethorphan</a> (DXM), <a href="/facts/Phencyclidine/4LaNo5Cl">phencyclidine</a> (PCP), <a href="/facts/Methoxetamine/y82sIHCj">methoxetamine</a> (MXE), and <a href="/facts/Nitrous_oxide/Jvys91lI">nitrous oxide</a> (N2O), are sometimes used as <a href="/facts/Recreational_drug/eoBD3vKn">recreational drugs</a>, for their dissociative, <a href="/facts/Hallucinogen/gn35weCu">hallucinogenic</a>, and <a href="/facts/Euphoriant/u4cnbWC4">euphoriant</a> properties. When used recreationally, they are classified as <a href="/facts/Dissociative_drug/5aaD39vM">dissociative drugs</a>. </p>