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Intermittent hypoxic therapy
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<h2 id="effects">Effects</h2> <p>A number of effects are reported.<a class="footnote-ref" id="fnref:2" href="#fn:2"><sup>2</sup></a><a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> It is important to differentiate between physiological adaptations to mild hypoxia and re-oxygenation episodes (i.e., the IHT protocol) and frequent nocturnal suffocation awakenings produced by <a href="/facts/Sleep_apnea/mstY43ok">sleep apnea</a>, which might result in various pathologies.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p> <h2 id="applications">Applications</h2> <p>IHT has been used to try to improve performance in sports.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> and has been used in a number of health conditions.<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Buteyko_method/hPqRGxbI">Buteyko method</a></li> <li><a href="/facts/Hypoventilation_training/MSQWqwTn">Hypoventilation training</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Navarrete-Opazo, Angela; Mitchell, Gordon S. (15 November 2014). "Therapeutic potential of intermittent hypoxia: a matter of dose". Am J Physiol Regul Integr Comp Physiol. 307 (10): R1181 – R1197. doi:10.1152/ajpregu.00208.2014. PMC 4315448. PMID 25231353. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315448" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315448</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Manukhina EB, Downey HF, Mallet RT (April 2006). "Formation and Role of Nitric Oxide Stores in Adaptation to Hypoxia". Oxygen Transport to Tissue XXVII. Advances in Experimental Medicine and Biology. Vol. 231. pp. 343–65. doi:10.1007/0-387-29540-2_6. ISBN 978-0-387-29543-5. PMID 16565431. {{cite book}}: |journal= ignored (help) <a href="978-0-387-29543-5" target="_blank">978-0-387-29543-5</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Gore CJ, Clark SA, Saunders PU (September 2007). "Nonhematological mechanisms of improved sea-level performance after hypoxic exposure". Medicine and Science in Sports and Exercise. 39 (9): 1600–9. doi:10.1249/mss.0b013e3180de49d3. PMID 17805094. <a href="https://doi.org/10.1249%2Fmss.0b013e3180de49d3" target="_blank">https://doi.org/10.1249%2Fmss.0b013e3180de49d3</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Serebrovskaya TV, Manukhina EB, Smith ML, Downey HF, Mallet RT (June 2008). "Intermittent hypoxia: cause of or therapy for systemic hypertension?". Experimental Biology and Medicine. 233 (6): 627–50. doi:10.3181/0710-MR-267. PMID 18408145. S2CID 20045656. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Levine, BD (2002). "Intermittent hypoxic training: fact and fancy". High Altitude Medicine & Biology. 3 (2): 177–93. doi:10.1089/15270290260131911. PMID 12162862. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Serebrovskaya TV (2002). "Intermittent hypoxia research in the former soviet union and the commonwealth of independent States: history and review of the concept and selected applications". High Altitude Medicine & Biology. 3 (2): 205–21. doi:10.1089/15270290260131939. PMID 12162864. S2CID 28834625. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> </ol>