Albuquerque begun his professional career working in advertising, doing work for local companies. He began his comic book career in 2002, after posting his portfolio on the Internet, doing work for the Egyptian publishing company AK Comics, which published books for the Middle East.
Albuquerque first gained the notice of U.S. comics readers with his work as the regular artist on the DC Comics monthly series Blue Beetle, which he drew from issues #10 (February 2007) to #34 (February 2009). The series proved to be a challenge to Albuquerque, who thought the mainstream superhero book was not well-suited to his darker style, and approached the book by employing less heavy blacks and ink splats, and a more "cartoony" storytelling style. His other DC work has included covers of several titles, as well as interior work on issues #52 and #53 of Superman/Batman. and the Robin/Spoiler Special #1 in 2008. That same year, Albuquerque illustrated writer Ivan Brandon's story, "Wild Goose", which appeared in the Dark Horse Comics anthology Tales of the Fear Agent. In 2009 he drew issues #3 and #4 of Strange Adventures and drew the covers to Marvel Comics' four-issue miniseries Nomad: Girl Without a World.
In 2012 Albuquerque illustrated and wrote his first story for DC Comics, which appeared in Legends of the Dark Knight. He drew backup stories for Batman vol. 2 #21–23 (August–October 2013) as part of the "Batman: Zero Year" storyline.
Albuquerque lives in Porto Alegre, Brazil.
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"About". Rafaelalbuquerque.com. n.d. Archived from the original on September 29, 2015. http://rafaelalbuquerque.com/about/
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Rafael Albuquerque at the Grand Comics Database https://www.comics.org/search.lasso/?sort=chrono&query=Rafael+Albuquerque&type=credit
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"Juri Do 24º HQMIX Faz As Pre-Indicacoes" (in Portuguese). HQ Mix Award. March 29, 2012. Archived from the original on June 18, 2022. English translation at Google Translate http://trofeu-hqmix.blogspot.com/search?updated-min=2012-01-01T00:00:00-02:00&updated-max=2013-01-01T00:00:00-02:00&max-results=13
"Juri Do 24º HQMIX Faz As Pre-Indicacoes" (in Portuguese). HQ Mix Award. March 29, 2012. Archived from the original on June 18, 2022. English translation at Google Translate http://trofeu-hqmix.blogspot.com/search?updated-min=2012-01-01T00:00:00-02:00&updated-max=2013-01-01T00:00:00-02:00&max-results=13
Melrose, Kevin (September 7, 2011). "Nominees announced for Spike TV's 2011 Scream Awards". Comic Book Resources. Archived from the original on September 8, 2015. http://robot6.comicbookresources.com/2011/09/nominees-announced-for-spike-tvs-2011-scream-awards/
Melrose, Kevin (September 7, 2011). "Nominees announced for Spike TV's 2011 Scream Awards". Comic Book Resources. Archived from the original on September 8, 2015. http://robot6.comicbookresources.com/2011/09/nominees-announced-for-spike-tvs-2011-scream-awards/
Hope, Larson (May 2018). All summer long. ISBN 978-0-374-30485-0. OCLC 994315474. 978-0-374-30485-0