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Electrical synapse
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<h2 id="structure">Structure</h2> <p>Each gap junction (sometimes called a <i>nexus</i>) contains numerous gap junction <a href="/facts/Ion_channel/A46LARFH">channels</a> that cross the <a href="/facts/Cell_membrane/vAXSD0DT">plasma membranes</a> of both cells.<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a> With a lumen diameter of about 1.2 to 2.0 nm,<a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a><a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a> the pore of a gap junction channel is wide enough to allow ions and even medium-size molecules like signaling molecules to flow from one cell to the next,<a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a><a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a> thereby connecting the two cells' <a href="/facts/Cytoplasm/Wa0sE6xf">cytoplasm</a>. Thus when the <a href="/facts/Membrane_potential/DpNG14c7">membrane potential</a> of one cell changes, <a href="/facts/Ion/3bePpDna">ions</a> may move through from one cell to the next, carrying positive charge with them and depolarizing the postsynaptic cell. </p><p>Gap junction channels are composed of two hemichannels called <a href="/facts/Connexon/Nn1FYQJq">connexons</a> in vertebrates, one contributed by each cell at the <a href="/facts/Synapse/vdMRJCUn">synapse</a>.<a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a><a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a><a class="footnote-ref" id="fnref:20" href="#fn:20"><sup>20</sup></a> Connexons are formed by six 7.5 nm long, four-pass membrane-spanning <a href="/facts/Protein/Jxmagu3E">protein</a> subunits called <a href="/facts/Connexin/RK87nd90">connexins</a>, which may be identical or slightly different from one another.<a class="footnote-ref" id="fnref:21" href="#fn:21"><sup>21</sup></a> </p><p>An <a href="/facts/Autapse/7h6epo8H">autapse</a> is an electrical (or chemical) synapse formed when the axon of one neuron synapses with its own dendrites. </p> <h2 id="effects">Effects</h2> <p>They are found in many <a href="/facts/Gap_junction/nhAEWww4">regions</a> in animal and human body. The simplicity of electrical synapses results in synapses that are fast, but more importantly the bidirectional coupling can produce very complex behaviors at the network level.<a class="footnote-ref" id="fnref:22" href="#fn:22"><sup>22</sup></a> </p> <ul><li>Without the need for receptors to recognize chemical messengers, signal transmission at electrical synapses is more rapid than that which occurs across chemical synapses, the predominant kind of junctions between neurons. Chemical transmission exhibits synaptic delay—recordings from squid synapses and neuromuscular junctions of the frog reveal a delay of 0.5 to 4.0 milliseconds—whereas electrical transmission takes place with almost no delay. However, the difference in speed between chemical and electrical synapses is not as marked in mammals as it is in cold-blooded animals.<a class="footnote-ref" id="fnref:23" href="#fn:23"><sup>23</sup></a></li> <li>Because electrical synapses do not involve neurotransmitters, electrical neurotransmission is less modifiable than chemical neurotransmission.</li> <li>The response always has the same sign as the source. For example, <a href="/facts/Depolarization/qGX8lFXE">depolarization</a> of the pre-synaptic membrane will always induce a depolarization in the post-synaptic membrane, and vice versa for <a href="/facts/Hyperpolarization_(biology)/XNH4zPwN">hyperpolarization</a>.</li> <li>The response in the postsynaptic neuron is in general smaller in amplitude than the source. The amount of attenuation of the signal is due to the membrane <a href="/facts/Electrical_resistance_and_conductance/hxSt0UAj">resistance</a> of the presynaptic and postsynaptic neurons.</li> <li>Long-term changes can be seen in electrical synapses. For example, changes in electrical synapses in the <a href="/facts/Retina/v0ISNX2S">retina</a> are seen during light and dark adaptations of the retina.<a class="footnote-ref" id="fnref:24" href="#fn:24"><sup>24</sup></a></li></ul> <p>The relative speed of electrical synapses also allows for many neurons to fire synchronously.<a class="footnote-ref" id="fnref:25" href="#fn:25"><sup>25</sup></a><a class="footnote-ref" id="fnref:26" href="#fn:26"><sup>26</sup></a><a class="footnote-ref" id="fnref:27" href="#fn:27"><sup>27</sup></a> Because of the speed of transmission, electrical synapses are found in escape mechanisms and other processes that require quick responses, such as the response to danger of the <a href="/facts/Sea_hare/erwMFpLS">sea hare</a> <i><a href="/facts/Aplysia/NzU0uLKI">Aplysia</a></i>, which quickly releases large quantities of ink to obscure enemies' vision.<a class="footnote-ref" id="fnref:28" href="#fn:28"><sup>28</sup></a> </p><p>Normally, current carried by ions could travel in either direction through this type of synapse.<a class="footnote-ref" id="fnref:29" href="#fn:29"><sup>29</sup></a> However, sometimes the junctions are rectifying synapses,<a class="footnote-ref" id="fnref:30" href="#fn:30"><sup>30</sup></a> containing <a href="/facts/Voltage-gated_ion_channel/PwgWQn8s">voltage-gated ion channels</a> that open in response to <a href="/facts/Depolarization/qGX8lFXE">depolarization</a> of an axon's plasma membrane, and prevent current from traveling in one of the two directions.<a class="footnote-ref" id="fnref:31" href="#fn:31"><sup>31</sup></a> Some channels may also close in response to increased <a href="/facts/Calcium_in_biology/wgUxKej5">calcium</a> (Ca2+) or <a href="/facts/Hydrogen/BoYHjl0J">hydrogen</a> (H+) ion concentration, so as not to spread damage from one cell to another.<a class="footnote-ref" id="fnref:32" href="#fn:32"><sup>32</sup></a> </p><p>There is also evidence of <a href="/facts/Synaptic_plasticity/rdVFxItN">synaptic plasticity</a> where the electrical connection established can either be strengthened or weakened as a result of activity, or during changes in the intracellular concentration of magnesium.<a class="footnote-ref" id="fnref:33" href="#fn:33"><sup>33</sup></a><a class="footnote-ref" id="fnref:34" href="#fn:34"><sup>34</sup></a> </p><p>Electrical synapses are present throughout the <a href="/facts/Central_nervous_system/k8I6To97">central nervous system</a> and have been studied specifically in the <a href="/facts/Neocortex/YEVjPgGK">neocortex</a>, <a href="/facts/Hippocampus/X7CqbP8X">hippocampus</a>, <a href="/facts/Thalamic_reticular_nucleus/4R4VUQN8">thalamic reticular nucleus</a>, <a href="/facts/Locus_coeruleus/tIYVuhGt">locus coeruleus</a>, <a href="/facts/Inferior_olivary_nucleus/YawcWPvj">inferior olivary nucleus</a>, <a href="/facts/Mesencephalic_nucleus_of_the_trigeminal_nerve/2vXTvym9">mesencephalic nucleus of the trigeminal nerve</a>, <a href="/facts/Olfactory_bulb/P2xEB4es">olfactory bulb</a>, <a href="/facts/Retina/v0ISNX2S">retina</a>, and <a href="/facts/Spinal_cord/XbWLr917">spinal cord</a> of <a href="/facts/Vertebrate/tT54FSTT">vertebrates</a>.<a class="footnote-ref" id="fnref:35" href="#fn:35"><sup>35</sup></a> Other examples of functional gap junctions detected <i>in vivo</i> are in the <a href="/facts/Striatum/MjNnTjSd">striatum</a>, <a href="/facts/Cerebellum/kBRS2Lou">cerebellum</a>, and <a href="/facts/Suprachiasmatic_nucleus/SILs86zl">suprachiasmatic nucleus</a>.<a class="footnote-ref" id="fnref:36" href="#fn:36"><sup>36</sup></a><a class="footnote-ref" id="fnref:37" href="#fn:37"><sup>37</sup></a> </p> <h2 id="history">History</h2> <p>The model of a reticular network of directly interconnected cells was one of the early hypotheses for the organization of the nervous system at the beginning of the 20th century. This <a href="/facts/Reticular_theory/uBcBK7eo">reticular hypothesis</a> was considered to conflict directly with the now predominant <i><a href="/facts/Neuron_doctrine/kXGAzI0o">neuron doctrine</a></i>, a model in which isolated, individual neurons signal to each other chemically across synaptic gaps. These two models came into sharp contrast at the award ceremony for the 1906 <a href="/facts/Nobel_Prize_in_Physiology_or_Medicine/rlnpJX84">Nobel Prize in Physiology or Medicine</a>, in which the award went jointly to <a href="/facts/Camillo_Golgi/Yq3cs6JY">Camillo Golgi</a>, a reticularist and widely recognized cell biologist, and <a href="/facts/Santiago_Ram%25C3%25B3n_y_Cajal/EUCn9yFv">Santiago Ramón y Cajal</a>, the champion of the <a href="/facts/Neuron_doctrine/kXGAzI0o">neuron doctrine</a> and the father of modern neuroscience. Golgi delivered his Nobel lecture first, in part detailing evidence for a reticular model of the nervous system. Ramón y Cajal then took the podium and refuted Golgi's conclusions in his lecture. Modern understanding of the coexistence of chemical and electrical synapses, however, suggests that both models are physiologically significant; it could be said that the <a href="/facts/Nobel_Prize/3z1Y3oFL">Nobel committee</a> acted with great foresight in awarding the Prize jointly. </p><p>There was substantial debate on whether the transmission of information between neurons was chemical or electrical in the first decades of the twentieth century, but chemical synaptic transmission was seen as the only answer after <a href="/facts/Otto_Loewi/AvP3kcK8">Otto Loewi</a>'s demonstration of chemical communication between neurons and heart muscle. Thus, the discovery of electrical communication was surprising. </p><p>Electrical synapses were first demonstrated between escape-related giant neurons in <a href="/facts/Crayfish/aXYaXaV8">crayfish</a> in the late 1950s,<a class="footnote-ref" id="fnref:38" href="#fn:38"><sup>38</sup></a> and were later found in vertebrates.<a class="footnote-ref" id="fnref:39" href="#fn:39"><sup>39</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Junctional_complex/tJ4ItRfq">Junctional complex</a></li> <li><a href="/facts/Cardiac_muscle/oMqU4Sdu">Cardiac muscle</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Andrew L. Harris; Darren Locke (2009). <a href="https://www.springer.com/978-1-934115-46-6"><i>Connexins, a guide</i></a>. New York: Springer. p. 574. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-1-934115-46-6.</li> <li>Haas, Julie S.; Baltazar Zavala; Carole E. Landisman (2011). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921920">"Activity-dependent long-term depression of electrical synapses"</a>. <i>Science</i>. 334 (6054): 389–393. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2011Sci...334..389H">2011Sci...334..389H</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1126%2Fscience.1207502">10.1126/science.1207502</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921920">10921920</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/22021860">22021860</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:35398480">35398480</a>.</li> <li>Hestrin, Shaul (2011). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458844">"The strength of electrical synapses"</a>. <i>Science</i>. 334 (6054): 315–316. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2011Sci...334..315H">2011Sci...334..315H</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1126%2Fscience.1213894">10.1126/science.1213894</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458844">4458844</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/22021844">22021844</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Kandel, ER; Schwartz, JH; Jessell, TM (2000). Principles of Neural Science (4th ed.). New York: McGraw-Hill. ISBN 978-0-8385-7701-1. <a href="978-0-8385-7701-1" target="_blank">978-0-8385-7701-1</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Hormuzdi SG, Filippov MA, Mitropoulou G, Monyer H, Bruzzone R (March 2004). "Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks". Biochim. Biophys. Acta. 1662 (1–2): 113–37. doi:10.1016/j.bbamem.2003.10.023. PMID 15033583. <a href="https://doi.org/10.1016%2Fj.bbamem.2003.10.023" target="_blank">https://doi.org/10.1016%2Fj.bbamem.2003.10.023</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Kandel, ER; Schwartz, JH; Jessell, TM (2000). Principles of Neural Science (4th ed.). New York: McGraw-Hill. ISBN 978-0-8385-7701-1. <a href="978-0-8385-7701-1" target="_blank">978-0-8385-7701-1</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Purves, Dale; Williams, Stephen Mark, eds. (2004). Neuroscience (3rd ed.). Sunderland, Mass: Sinauer Associates. ISBN 978-0-87893-915-2. <a href="978-0-87893-915-2" target="_blank">978-0-87893-915-2</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Bennett, M. V. L. (1966). "PHYSIOLOGY OF ELECTROTONIC JUNCTIONS*". Annals of the New York Academy of Sciences. 137 (2): 509–539. doi:10.1111/j.1749-6632.1966.tb50178.x. ISSN 0077-8923. <a href="https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1966.tb50178.x" target="_blank">https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1966.tb50178.x</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Connors, Barry W.; Long, Michael A. (2004-07-21). "ELECTRICAL SYNAPSES IN THE MAMMALIAN BRAIN". Annual Review of Neuroscience. 27 (1): 393–418. doi:10.1146/annurev.neuro.26.041002.131128. ISSN 0147-006X. <a href="https://www.annualreviews.org/doi/10.1146/annurev.neuro.26.041002.131128" target="_blank">https://www.annualreviews.org/doi/10.1146/annurev.neuro.26.041002.131128</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Connors, Barry W.; Long, Michael A. (2004-07-21). "ELECTRICAL SYNAPSES IN THE MAMMALIAN BRAIN". Annual Review of Neuroscience. 27 (1): 393–418. doi:10.1146/annurev.neuro.26.041002.131128. ISSN 0147-006X. <a href="https://www.annualreviews.org/doi/10.1146/annurev.neuro.26.041002.131128" target="_blank">https://www.annualreviews.org/doi/10.1146/annurev.neuro.26.041002.131128</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Bennett, Michael V.L; Zukin, R.Suzanne (2004). "Electrical Coupling and Neuronal Synchronization in the Mammalian Brain". Neuron. 41 (4): 495–511. doi:10.1016/S0896-6273(04)00043-1. <a href="https://linkinghub.elsevier.com/retrieve/pii/S0896627304000431" target="_blank">https://linkinghub.elsevier.com/retrieve/pii/S0896627304000431</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Makarenko, Vladimir; Llinás, Rodolfo (1998-12-22). "Experimentally determined chaotic phase synchronization in a neuronal system". Proceedings of the National Academy of Sciences. 95 (26): 15747–15752. doi:10.1073/pnas.95.26.15747. ISSN 0027-8424. PMC 28115. PMID 9861041. <a href="https://pnas.org/doi/full/10.1073/pnas.95.26.15747" target="_blank">https://pnas.org/doi/full/10.1073/pnas.95.26.15747</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Korn, Henri; Faure, Philippe (2003-09-01). "Is there chaos in the brain? II. Experimental evidence and related models". Comptes Rendus. Biologies. 326 (9): 787–840. doi:10.1016/j.crvi.2003.09.011. ISSN 1768-3238. <a href="https://comptes-rendus.academie-sciences.fr/biologies/articles/10.1016/j.crvi.2003.09.011/" target="_blank">https://comptes-rendus.academie-sciences.fr/biologies/articles/10.1016/j.crvi.2003.09.011/</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>Purves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; James O. McNamara & Leonard E. White (2008). Neuroscience (4th ed.). Sinauer Associates. pp. 85–88. ISBN 978-0-87893-697-7. <a href="978-0-87893-697-7" target="_blank">978-0-87893-697-7</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>Purves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; Richard D. Mooney; Leonard E. White & Michael L. Platt (2018). Neuroscience (6th ed.). Oxford University Press. pp. 86–87. ISBN 978-1605353807. <a href="978-1605353807" target="_blank">978-1605353807</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> <li id="fn:13"><p>Gibson JR, Beierlein M, Connors BW (January 2005). "Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4". J. Neurophysiol. 93 (1): 467–80. doi:10.1152/jn.00520.2004. PMID 15317837. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></p></li> <li id="fn:14"><p>Hormuzdi SG, Filippov MA, Mitropoulou G, Monyer H, Bruzzone R (March 2004). "Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks". Biochim. Biophys. Acta. 1662 (1–2): 113–37. doi:10.1016/j.bbamem.2003.10.023. PMID 15033583. <a href="https://doi.org/10.1016%2Fj.bbamem.2003.10.023" target="_blank">https://doi.org/10.1016%2Fj.bbamem.2003.10.023</a> <a href="#fnref:14" class="footnote-back-ref">↩</a></p></li> <li id="fn:15"><p>Bennett MV, Zukin RS (February 2004). "Electrical coupling and neuronal synchronization in the Mammalian brain". Neuron. 41 (4): 495–511. doi:10.1016/S0896-6273(04)00043-1. PMID 14980200. S2CID 18566176. <a href="https://doi.org/10.1016%2FS0896-6273%2804%2900043-1" target="_blank">https://doi.org/10.1016%2FS0896-6273%2804%2900043-1</a> <a href="#fnref:15" class="footnote-back-ref">↩</a></p></li> <li id="fn:16"><p>Hormuzdi SG, Filippov MA, Mitropoulou G, Monyer H, Bruzzone R (March 2004). "Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks". Biochim. Biophys. Acta. 1662 (1–2): 113–37. doi:10.1016/j.bbamem.2003.10.023. PMID 15033583. <a href="https://doi.org/10.1016%2Fj.bbamem.2003.10.023" target="_blank">https://doi.org/10.1016%2Fj.bbamem.2003.10.023</a> <a href="#fnref:16" class="footnote-back-ref">↩</a></p></li> <li id="fn:17"><p>Kandel, Schwartz & Jessell 2000, pp. 178–180 - Kandel, ER; Schwartz, JH; Jessell, TM (2000). Principles of Neural Science (4th ed.). New York: McGraw-Hill. ISBN 978-0-8385-7701-1. <a href="#fnref:17" class="footnote-back-ref">↩</a></p></li> <li id="fn:18"><p>Hormuzdi SG, Filippov MA, Mitropoulou G, Monyer H, Bruzzone R (March 2004). "Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks". Biochim. Biophys. Acta. 1662 (1–2): 113–37. doi:10.1016/j.bbamem.2003.10.023. PMID 15033583. <a href="https://doi.org/10.1016%2Fj.bbamem.2003.10.023" target="_blank">https://doi.org/10.1016%2Fj.bbamem.2003.10.023</a> <a href="#fnref:18" class="footnote-back-ref">↩</a></p></li> <li id="fn:19"><p>Bennett MV, Zukin RS (February 2004). "Electrical coupling and neuronal synchronization in the Mammalian brain". Neuron. 41 (4): 495–511. doi:10.1016/S0896-6273(04)00043-1. PMID 14980200. S2CID 18566176. <a href="https://doi.org/10.1016%2FS0896-6273%2804%2900043-1" target="_blank">https://doi.org/10.1016%2FS0896-6273%2804%2900043-1</a> <a href="#fnref:19" class="footnote-back-ref">↩</a></p></li> <li id="fn:20"><p>Kandel, Schwartz & Jessell 2000, p. 178 - Kandel, ER; Schwartz, JH; Jessell, TM (2000). Principles of Neural Science (4th ed.). New York: McGraw-Hill. ISBN 978-0-8385-7701-1. <a href="#fnref:20" class="footnote-back-ref">↩</a></p></li> <li id="fn:21"><p>Bennett MV, Zukin RS (February 2004). "Electrical coupling and neuronal synchronization in the Mammalian brain". Neuron. 41 (4): 495–511. doi:10.1016/S0896-6273(04)00043-1. PMID 14980200. S2CID 18566176. <a href="https://doi.org/10.1016%2FS0896-6273%2804%2900043-1" target="_blank">https://doi.org/10.1016%2FS0896-6273%2804%2900043-1</a> <a href="#fnref:21" class="footnote-back-ref">↩</a></p></li> <li id="fn:22"><p>Rydin Gorjão, Leonardo; Saha, Arindam; Ansmann, Gerrit; Feudel, Ulrike; Lehnertz, Klaus (2018-10-01). "Complexity and irreducibility of dynamics on networks of networks". Chaos: An Interdisciplinary Journal of Nonlinear Science. 28 (10). arXiv:1808.00305. doi:10.1063/1.5039483. ISSN 1054-1500. <a href="https://pubs.aip.org/aip/cha/article-abstract/28/10/106306/1051711/Complexity-and-irreducibility-of-dynamics-on?redirectedFrom=fulltext" target="_blank">https://pubs.aip.org/aip/cha/article-abstract/28/10/106306/1051711/Complexity-and-irreducibility-of-dynamics-on?redirectedFrom=fulltext</a> <a href="#fnref:22" class="footnote-back-ref">↩</a></p></li> <li id="fn:23"><p>Bennett MV, Zukin RS (February 2004). "Electrical coupling and neuronal synchronization in the Mammalian brain". Neuron. 41 (4): 495–511. doi:10.1016/S0896-6273(04)00043-1. PMID 14980200. S2CID 18566176. <a href="https://doi.org/10.1016%2FS0896-6273%2804%2900043-1" target="_blank">https://doi.org/10.1016%2FS0896-6273%2804%2900043-1</a> <a href="#fnref:23" class="footnote-back-ref">↩</a></p></li> <li id="fn:24"><p>Dr. John O'Brien || Faculty Biography || The Department of Ophthalmology and Visual Science at the University of Texas Medical School at Houston <a href="https://med.uth.edu/ibp/faculty/john-obrien/" target="_blank">https://med.uth.edu/ibp/faculty/john-obrien/</a> <a href="#fnref:24" class="footnote-back-ref">↩</a></p></li> <li id="fn:25"><p>Gibson JR, Beierlein M, Connors BW (January 2005). "Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4". J. Neurophysiol. 93 (1): 467–80. doi:10.1152/jn.00520.2004. PMID 15317837. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:25" class="footnote-back-ref">↩</a></p></li> <li id="fn:26"><p>Bennett MV, Zukin RS (February 2004). "Electrical coupling and neuronal synchronization in the Mammalian brain". Neuron. 41 (4): 495–511. doi:10.1016/S0896-6273(04)00043-1. PMID 14980200. S2CID 18566176. <a href="https://doi.org/10.1016%2FS0896-6273%2804%2900043-1" target="_blank">https://doi.org/10.1016%2FS0896-6273%2804%2900043-1</a> <a href="#fnref:26" class="footnote-back-ref">↩</a></p></li> <li id="fn:27"><p>Kandel, Schwartz & Jessell 2000, p. 180 - Kandel, ER; Schwartz, JH; Jessell, TM (2000). Principles of Neural Science (4th ed.). New York: McGraw-Hill. ISBN 978-0-8385-7701-1. <a href="#fnref:27" class="footnote-back-ref">↩</a></p></li> <li id="fn:28"><p>Kandel, ER; Schwartz, JH; Jessell, TM (2000). Principles of Neural Science (4th ed.). New York: McGraw-Hill. ISBN 978-0-8385-7701-1. <a href="978-0-8385-7701-1" target="_blank">978-0-8385-7701-1</a> <a href="#fnref:28" class="footnote-back-ref">↩</a></p></li> <li id="fn:29"><p>Hormuzdi SG, Filippov MA, Mitropoulou G, Monyer H, Bruzzone R (March 2004). "Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks". Biochim. Biophys. Acta. 1662 (1–2): 113–37. doi:10.1016/j.bbamem.2003.10.023. PMID 15033583. <a href="https://doi.org/10.1016%2Fj.bbamem.2003.10.023" target="_blank">https://doi.org/10.1016%2Fj.bbamem.2003.10.023</a> <a href="#fnref:29" class="footnote-back-ref">↩</a></p></li> <li id="fn:30"><p>Hormuzdi SG, Filippov MA, Mitropoulou G, Monyer H, Bruzzone R (March 2004). "Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks". Biochim. Biophys. Acta. 1662 (1–2): 113–37. doi:10.1016/j.bbamem.2003.10.023. PMID 15033583. <a href="https://doi.org/10.1016%2Fj.bbamem.2003.10.023" target="_blank">https://doi.org/10.1016%2Fj.bbamem.2003.10.023</a> <a href="#fnref:30" class="footnote-back-ref">↩</a></p></li> <li id="fn:31"><p>Kandel, Schwartz & Jessell 2000, p. 180 - Kandel, ER; Schwartz, JH; Jessell, TM (2000). Principles of Neural Science (4th ed.). New York: McGraw-Hill. ISBN 978-0-8385-7701-1. <a href="#fnref:31" class="footnote-back-ref">↩</a></p></li> <li id="fn:32"><p>Kandel, Schwartz & Jessell 2000, p. 180 - Kandel, ER; Schwartz, JH; Jessell, TM (2000). Principles of Neural Science (4th ed.). New York: McGraw-Hill. ISBN 978-0-8385-7701-1. <a href="#fnref:32" class="footnote-back-ref">↩</a></p></li> <li id="fn:33"><p>Palacios-Prado, Nicolas; et al. (Mar 2013). "Intracellular magnesium-dependent modulation of gap junction channels formed by neuronal connexin36". Journal of Neuroscience. 33 (11): 4741–53. doi:10.1523/JNEUROSCI.2825-12.2013. PMC 3635812. PMID 23486946. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635812" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635812</a> <a href="#fnref:33" class="footnote-back-ref">↩</a></p></li> <li id="fn:34"><p>Activity-Dependent; Synapses, Electrical; Haas, Julie S.; et al. (2011). "Activity-dependent long-term depression of electrical synapses". Science. 334 (6054): 389–93. Bibcode:2011Sci...334..389H. doi:10.1126/science.1207502. PMC 10921920. PMID 22021860. S2CID 35398480. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921920" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921920</a> <a href="#fnref:34" class="footnote-back-ref">↩</a></p></li> <li id="fn:35"><p>Electrical synapses in the mammalian brain, Connors & Long, "Annu Rev Neurosci" 2004;27:393-418 <a href="#fnref:35" class="footnote-back-ref">↩</a></p></li> <li id="fn:36"><p>Eugenin, Eliseo A.; Basilio, Daniel; Sáez, Juan C.; Orellana, Juan A.; Raine, Cedric S.; Bukauskas, Feliksas; Bennett, Michael V. L.; Berman, Joan W. (2012-09-01). "The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system". Journal of Neuroimmune Pharmacology. 7 (3): 499–518. doi:10.1007/s11481-012-9352-5. ISSN 1557-1904. PMC 3638201. PMID 22438035. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638201" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638201</a> <a href="#fnref:36" class="footnote-back-ref">↩</a></p></li> <li id="fn:37"><p>Pereda, Alberto E.; Curti, Sebastian; Hoge, Gregory; Cachope, Roger; Flores, Carmen E.; Rash, John E. (2013-01-01). "Gap junction-mediated electrical transmission: regulatory mechanisms and plasticity". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828 (1): 134–146. doi:10.1016/j.bbamem.2012.05.026. ISSN 0006-3002. PMC 3437247. PMID 22659675. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437247" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437247</a> <a href="#fnref:37" class="footnote-back-ref">↩</a></p></li> <li id="fn:38"><p>Pappas, George D.; Bennett, Michael V. L. (1966). "Specialized junctions involved in electrical transmission between neurons". Annals of the New York Academy of Sciences. 137 (2): 495–508. doi:10.1111/j.1749-6632.1966.tb50177.x. ISSN 0077-8923. <a href="https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1966.tb50177.x" target="_blank">https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1966.tb50177.x</a> <a href="#fnref:38" class="footnote-back-ref">↩</a></p></li> <li id="fn:39"><p>Purves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; James O. McNamara & Leonard E. White (2008). Neuroscience (4th ed.). Sinauer Associates. pp. 85–88. ISBN 978-0-87893-697-7. <a href="978-0-87893-697-7" target="_blank">978-0-87893-697-7</a> <a href="#fnref:39" class="footnote-back-ref">↩</a></p></li> </ol>