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Perisinusoidal space
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<h2 id="pathophysiology">Pathophysiology</h2> <h3>Fibrosis</h3> <p>Liver injury from a number of causes can activate the hepatic stellate cells into <a href="/facts/Transdifferentiated/PJbRVgR0">transdifferentiated</a> and prolific <a href="/facts/Myofibroblast/n7YgT95j">myofibroblasts</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> The myofibroblasts synthesize and secrete components of the <a href="/facts/Extracellular_matrix/kaHC5Ez8">extracellular matrix</a> including <a href="/facts/Collagen/KsyAb72K">collagen</a> into the perisinusoidal space.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> This in turn promotes the development of <a href="/facts/Fibrosis/VVSmVgr3">fibrosis</a>, and continuing fibrosis is thought to be responsible for the development of <a href="/facts/Cirrhosis/bkLuLvCD">cirrhosis</a>, and <a href="/facts/Liver_cancer/a7N4vD4L">liver cancer</a>.<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p> <h2 id="external-links">External links</h2> <ul><li><a href="/facts/College_of_Medicine_at_Urbana-Champaign/UNABXxly">UIUC Histology Subject</a> <i><a href="https://histo.life.illinois.edu/histo/atlas/oimages.php?oid=1317">1317</a></i></li> <li><a href="https://www.bu.edu/phpbin/medlib/histology/p/22103loa.htm">Histology image: 22103loa</a> – Histology Learning System at Boston University - "Ultrastructure of the Cell: hepatocytes and sinusoids, sinusoid and space of Disse"</li> <li><a href="https://www.bu.edu/phpbin/medlib/histology/p/15204loa.htm">Histology image: 15204loa</a> – Histology Learning System at Boston University - "Liver, Gall Bladder, and Pancreas: liver; sinusoids and Kupffer cells"</li> <li><a href="https://web.archive.org/web/20081020010317/http://trc.ucdavis.edu/mjguinan/apc100/modules/digestive/mammal/liver5/liver7.html">Anatomy photo: digestive/mammal/liver5/liver7</a> - Comparative Organology at University of California, Davis - "Mammal, liver (EM, Low)"</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Robbins, Stanley L.; Cotran, Ramzi S.; Kumar, Vinay; Collins, Tucker (1999). Robbins pathologic basis of disease. Philadelphia: Saunders. ISBN 0-7216-7335-X. <a href="0-7216-7335-X" target="_blank">0-7216-7335-X</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Kumar, Vinay; Abbas, Abul K.; Aster, Jon C.; Robbins, Stanley L.; Perkins, James A. (2018). Robbins basic pathology (Tenth ed.). Philadelphia, Pennsylvania: Elsevier. p. 637. ISBN 9780323353175. <a href="9780323353175" target="_blank">9780323353175</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Haubrich WS (2004). "Disse of the space of Disse". Gastroenterology. 127 (6): 1684. doi:10.1053/j.gastro.2004.10.021. PMID 15578505. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Tacke, F; Weiskirchen, R (February 2012). "Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques". Expert Review of Gastroenterology & Hepatology. 6 (1): 67–80. doi:10.1586/egh.11.92. PMID 22149583. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Tacke, F; Weiskirchen, R (February 2012). "Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques". Expert Review of Gastroenterology & Hepatology. 6 (1): 67–80. doi:10.1586/egh.11.92. PMID 22149583. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Cheng, S; Zou, Y; Zhang, M (October 2023). "Single-cell RNA sequencing reveals the heterogeneity and intercellular communication of hepatic stellate cells and macrophages during liver fibrosis". MedComm. 4 (5): e378. doi:10.1002/mco2.378. PMC 10505372. PMID 37724132. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505372" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505372</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> </ol>